Protein Info for CSW01_17615 in Vibrio cholerae E7946 ATCC 55056

Annotation: MFS transporter family glucose-6-phosphate receptor UhpC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 436 transmembrane" amino acids 21 to 39 (19 residues), see Phobius details amino acids 60 to 80 (21 residues), see Phobius details amino acids 91 to 138 (48 residues), see Phobius details amino acids 150 to 173 (24 residues), see Phobius details amino acids 180 to 198 (19 residues), see Phobius details amino acids 246 to 264 (19 residues), see Phobius details amino acids 280 to 303 (24 residues), see Phobius details amino acids 315 to 333 (19 residues), see Phobius details amino acids 339 to 360 (22 residues), see Phobius details amino acids 372 to 395 (24 residues), see Phobius details amino acids 402 to 423 (22 residues), see Phobius details PF07690: MFS_1" amino acids 31 to 391 (361 residues), 179.7 bits, see alignment E=3.9e-57 TIGR00881: phosphoglycerate transporter family protein" amino acids 31 to 408 (378 residues), 408.6 bits, see alignment E=1.3e-126

Best Hits

Swiss-Prot: 59% identical to UHPC_ECOLI: Membrane sensor protein UhpC (uhpC) from Escherichia coli (strain K12)

KEGG orthology group: K07783, MFS transporter, OPA family, sugar phosphate sensor protein UhpC (inferred from 100% identity to vcj:VCD_000641)

Predicted SEED Role

"Hexose phosphate uptake regulatory protein UhpC" in subsystem Hexose Phosphate Uptake System

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (436 amino acids)

>CSW01_17615 MFS transporter family glucose-6-phosphate receptor UhpC (Vibrio cholerae E7946 ATCC 55056)
MKIVPMVQPIQAMEIDQAYRHWRIHLMISMYVGYGVFYLTRKSFNFAMPQMLSELGLDYS
DLGFLSTLFYLTYGVSKFVSGLMIDRSRSPYFMGLGLMATGIINIAFGFSSSLLAFTLLW
TANAFFQGWGWPACAKVLTHWYSRSERGFWWSIWNTCHNLSGALIPIVIGFISLTFGWRY
GFLFAGGVAIFVGLWLCYRIQEKPSEMGLPSVGEWRGDALELEHEKEGQGLAFRVAVYRY
VLTNRYIWLLCGSYLLVYVVRIGINDWGSLYLVERHAYNILSANSAVAMFEVGGFLGSLL
GGWGSDYYFRGNRAPMNLIFALGIFASVAALWLTPIDHLWFLAGCFFCIGFFVFGPQMMI
GMAAAECARKDLAGTATGFVGLFSYLGAALASYPMSLAIEAWGWEGFFCLITAAAAVISL
QLLPFIKAQQPVTEDE