Protein Info for CSW01_17610 in Vibrio cholerae E7946 ATCC 55056

Annotation: signal transduction histidine-protein kinase/phosphatase UhpB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 527 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details transmembrane" amino acids 19 to 19 (1 residues), see Phobius details amino acids 55 to 74 (20 residues), see Phobius details amino acids 81 to 100 (20 residues), see Phobius details amino acids 107 to 131 (25 residues), see Phobius details amino acids 142 to 164 (23 residues), see Phobius details amino acids 190 to 208 (19 residues), see Phobius details amino acids 215 to 233 (19 residues), see Phobius details amino acids 263 to 282 (20 residues), see Phobius details PF05231: MASE1" amino acids 7 to 285 (279 residues), 203.8 bits, see alignment E=5.1e-64 PF07730: HisKA_3" amino acids 320 to 382 (63 residues), 49.6 bits, see alignment E=7.2e-17 PF02518: HATPase_c" amino acids 426 to 514 (89 residues), 43.2 bits, see alignment E=7.4e-15

Best Hits

KEGG orthology group: K07675, two-component system, NarL family, sensor histidine kinase UhpB [EC: 2.7.13.3] (inferred from 100% identity to vch:VCA0683)

Predicted SEED Role

"Sensor histidine protein kinase UhpB, glucose-6-phosphate specific (EC 2.7.13.3)" in subsystem Hexose Phosphate Uptake System (EC 2.7.13.3)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (527 amino acids)

>CSW01_17610 signal transduction histidine-protein kinase/phosphatase UhpB (Vibrio cholerae E7946 ATCC 55056)
MAKLFPLIFAFVLYSISQFSLWNVSQYLSHNPLQAYLLFPTGLRLAVYLLARPTYVWVWL
LSDMLLAGVILVLLPDQSSPLMLLMPWVVWLAAVIARQHWPKLHLYWQKLLLIVALVLLH
TILVGITFTLLAKPLHMGAETLIAVSIASLTGGIVLTPFLYLVADYLSHQTWHPLSPQLI
HHDVKLKPKMLMWSLLFFSLGLLAELTLLEQMKPFALLIILLPTIFLAYRYGWQGGVLAS
SLNCILLATARQFSGSFSSDQELLIFMSSQAFVGLGLGIAISRQHQLALLLQKMNTRLAK
ELREKQDLARQLVSVEEQIRKSVARELHDEIGQNITAIQIQSMLAERLASNDQAKQAASS
VQSLAMRIHQSTRQLLKQLRPHILDELGLEHAIRQLVQEMRFAEQGMTVRLNMGVNPQKL
DDTTRVTLYRIVQELLNNICKHAKATRVHISLFPGSEMVLEVKDDGIGLPTDWRVRGHGL
KGLSERVSALGGQLKMTSSTFQTGTRIIVNLPTKRSITSEKLGNIPR