Protein Info for CSW01_17055 in Vibrio cholerae E7946 ATCC 55056

Annotation: DNA-binding response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 218 PF00072: Response_reg" amino acids 6 to 112 (107 residues), 66.4 bits, see alignment E=2.6e-22 PF00486: Trans_reg_C" amino acids 145 to 216 (72 residues), 87 bits, see alignment E=7.1e-29

Best Hits

Swiss-Prot: 43% identical to YCLJ_BACSU: Uncharacterized transcriptional regulatory protein YclJ (yclJ) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_0500)

Predicted SEED Role

"Copper-sensing two-component system response regulator CusR" in subsystem Cobalt-zinc-cadmium resistance or Copper homeostasis or Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (218 amino acids)

>CSW01_17055 DNA-binding response regulator (Vibrio cholerae E7946 ATCC 55056)
MKQTLLLVEDDKNLADGLLVSLEQAGYDCLHAETIADVKQHWDKADLVILDRQLPDGDSV
QHLMDWKKIKDIPVILLTALVTVKDKVTGLDAGANDYLTKPFAEAELFARIRAQLRSPDS
GQDDSKVVTSNLTIDKATREVFFNGESITLTRTEFDLLLFLASNLGRVFTRDELLDHVWG
YNHFPTTRTVDTHVLQLRQKLPGLEIETLRGVGYKMKA