Protein Info for CSW01_15330 in Vibrio cholerae E7946 ATCC 55056

Annotation: glycine dehydrogenase (decarboxylating)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 954 PF02347: GDC-P" amino acids 17 to 438 (422 residues), 587 bits, see alignment E=2.3e-180 amino acids 458 to 736 (279 residues), 34.4 bits, see alignment E=1.2e-12 TIGR00461: glycine dehydrogenase" amino acids 17 to 946 (930 residues), 1490.6 bits, see alignment E=0 PF21478: GcvP2_C" amino acids 774 to 895 (122 residues), 202.4 bits, see alignment E=1.7e-64

Best Hits

Swiss-Prot: 78% identical to GCSP_ALIFM: Glycine dehydrogenase (decarboxylating) (gcvP) from Aliivibrio fischeri (strain MJ11)

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (954 amino acids)

>CSW01_15330 glycine dehydrogenase (decarboxylating) (Vibrio cholerae E7946 ATCC 55056)
MTELLHSLSTQNEFVARHNGPDKQEQATMLKTVNAESLDALIAQTVPAQIRLEAPMQLAP
AQSEADMLATMKSFAKLNQLKRTFIGQGYYNTFTPNVILRNVMENPGWYTAYTPYQPEIS
QGRLESLLNYQQMVMDLTAMEIANASLLDEATAAAEAMALCQRAGKSKSNLFFVADDVHP
QTIEVVKTRAAFLGFEVKVDSIDNITQQEAFGALLQYPGTTGEVRDLTDIIAKAQANKTL
VTVATDLLASVLLKPAGEMGADVVIGSAQRFGVPMGYGGPHAAFMATRDAHKRTMPGRVI
GVSIDAKGNQALRMAMQTREQHIRREKATSNICTAQALLANMAAFYAVYHGPQGLRTIAR
RAHHLTAILAAGLTKAGYELAHQHFFDTLAINTGAKTDALYQAAQQANINLRKLPNQLGV
SFDETTTVADVEALFAIFGIKEEVHALSDRIATNELAAIPESCRRQSAFLTHPVFNTHHS
ETQMLRYMKHLENKDFSLTHGMIPLGSCTMKLNATAEMIPVTWPEFGALHPFVPKAQAAG
YAALAEDLKQKLCEITGYDAFSLQPNSGASGEYAGLVAIQRYHQSRGEGHRNVCLIPSSA
HGTNPATAAMVSMKVVVVKCDENGNIDMVDLADKIEKHKDHLSSIMITYPSTHGVYEQQV
REVCEMVHAAGGQVYLDGANMNAQVGLTSPGFIGSDVSHLNLHKTFCIPHGGGGPGMGPI
GVKSHLAPFLPGHIEGGVEGSDFAVSAADLGSASILPISWAYIAMMGADGLAEATKLAIL
NANYVMERLRPHYPILYRGANGRVAHECIIDIRPLKEETGISEEDIAKRLMDYGFHAPTM
SFPVAGTLMVEPTESEDLAELDRFCDALIAIRGEIDKVKNGEWPLESNPLVHAPHTQADL
REEKWDRPYSREIACFPSAHTKASKYWPTVNRVDNVYGDRNLVCSCPSIDSYQD