Protein Info for CSW01_15200 in Vibrio cholerae E7946 ATCC 55056

Annotation: PTS ascorbate transporter subunit IIC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 586 transmembrane" amino acids 14 to 34 (21 residues), see Phobius details amino acids 46 to 66 (21 residues), see Phobius details amino acids 101 to 121 (21 residues), see Phobius details amino acids 133 to 153 (21 residues), see Phobius details amino acids 155 to 177 (23 residues), see Phobius details amino acids 232 to 253 (22 residues), see Phobius details amino acids 265 to 291 (27 residues), see Phobius details amino acids 306 to 370 (65 residues), see Phobius details amino acids 383 to 402 (20 residues), see Phobius details amino acids 425 to 449 (25 residues), see Phobius details PF03611: EIIC-GAT" amino acids 15 to 407 (393 residues), 363.8 bits, see alignment E=1.3e-112 PF02302: PTS_IIB" amino acids 491 to 565 (75 residues), 46.9 bits, see alignment E=3.6e-16

Best Hits

KEGG orthology group: K02822, PTS system, ascorbate-specific IIB component [EC: 2.7.1.69] K03475, PTS system, ascorbate-specific IIC component (inferred from 100% identity to vcm:VCM66_A0242)

Predicted SEED Role

"Ascorbate-specific PTS system, EIIC component" in subsystem L-ascorbate utilization (and related gene clusters)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (586 amino acids)

>CSW01_15200 PTS ascorbate transporter subunit IIC (Vibrio cholerae E7946 ATCC 55056)
MEFLYDVFYIFYSQVMTKAPLLLGLVTLIGYWLLRRDATTIIKGSIKTIVGFMLVQVGAG
TLVAGFKPVIEKLSQYHGLTGSVIDPYTSMMATMETMGDNYSWVGYAVLLALAINILLVL
FRRYTGIRTIMLTGHIMFQQAGLIAVFYFVLGAGMWETIIYSAVLMALYWGISSNIMFKP
TEEVTGGAGFSIGHQQQVASWIATKIAPKLGDKKDSVDHLQLPKWLHIFHDSIAATAIVM
TVFFGIILLSFGLDNLQEMAGSTHWTIYILETGLKFAVAIQVIVAGVRMFVAELSEAFKG
ISERVIPNAVLAIDCAAIYAFSPNAMVFGFMWGALGQFAAVLAMLAFNAPIMIIPGFIPM
FFSNATIGVFANHFGGWKAVMKICFVMGIIEVLGSAWAIHLFTQQGTEFSGWMGMADWAL
VFPPIMQGLSASKLFFFVLVALALVYMFFASKQLRAEEDAQGSITVSDEPEVIEAVEQAL
QAAQGTRPVSILAVCGNGQGSSMMMKMKIGKYLEQKGIPHVMDSCAVSDYKSKLATTDII
VSSKHLSAEMEPGEGKFVLGVQNMLNPNSFGNELLDIIHNHFVKIR