Protein Info for CSW01_15055 in Vibrio cholerae E7946 ATCC 55056

Annotation: Bcr/CflA family drug resistance efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 414 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 53 to 77 (25 residues), see Phobius details amino acids 89 to 106 (18 residues), see Phobius details amino acids 112 to 131 (20 residues), see Phobius details amino acids 149 to 169 (21 residues), see Phobius details amino acids 180 to 203 (24 residues), see Phobius details amino acids 226 to 250 (25 residues), see Phobius details amino acids 259 to 281 (23 residues), see Phobius details amino acids 291 to 311 (21 residues), see Phobius details amino acids 317 to 342 (26 residues), see Phobius details amino acids 354 to 374 (21 residues), see Phobius details amino acids 380 to 397 (18 residues), see Phobius details PF07690: MFS_1" amino acids 28 to 367 (340 residues), 149.3 bits, see alignment E=2.1e-47 PF00083: Sugar_tr" amino acids 57 to 128 (72 residues), 34.1 bits, see alignment E=2.2e-12

Best Hits

Swiss-Prot: 42% identical to EMRD_ECOLI: Multidrug resistance protein D (emrD) from Escherichia coli (strain K12)

KEGG orthology group: K08154, MFS transporter, DHA1 family, 2-module integral membrane pump EmrD (inferred from 100% identity to vco:VC0395_1015)

MetaCyc: 42% identical to multidrug efflux pump EmrD (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-339; TRANS-RXN-44

Predicted SEED Role

"Multidrug resistance protein D"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (414 amino acids)

>CSW01_15055 Bcr/CflA family drug resistance efflux transporter (Vibrio cholerae E7946 ATCC 55056)
MFLIRYCFYLEITMSASLSVAKLTFFIAILAAVGQATQTMYVPSIGYMAQEFLVSPAALQ
AVMACYLIPYGLSQFVYGTLSDRIGRKPIIIAGLAIYIIGSLIALFAHQYSWFLIGSFVQ
GLGIGCGGAMSRTLSRDCFEGAELHKVNSLISMCLIFSPLVAPVLGGYLTESFGWRSSYL
FLSLFAIAVVITMMTSMVETLPATARKKEPVLRSYHYVLSDRRFQGYLICLVATFAGLAV
FEAAAGVLLGGVLGLPATTVSLLFVLPIPGYLAGAWLSNVIARHWREKTAMHVGLLAILT
GSLVIMLPGLLGMTTALSLIGGATIYFLGAGILFPAATTGALSPFPYHAGTGGAILGGMQ
NLGAGLATLFAAMFPASDQLPLGIIMLLMSVLALWGLKRVYTKQPPSDEMPIAI