Protein Info for CSW01_14950 in Vibrio cholerae E7946 ATCC 55056

Annotation: sodium:proton antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 447 transmembrane" amino acids 13 to 36 (24 residues), see Phobius details amino acids 42 to 62 (21 residues), see Phobius details amino acids 83 to 102 (20 residues), see Phobius details amino acids 112 to 134 (23 residues), see Phobius details amino acids 143 to 158 (16 residues), see Phobius details amino acids 163 to 182 (20 residues), see Phobius details amino acids 205 to 224 (20 residues), see Phobius details amino acids 242 to 269 (28 residues), see Phobius details amino acids 285 to 305 (21 residues), see Phobius details amino acids 347 to 366 (20 residues), see Phobius details amino acids 388 to 411 (24 residues), see Phobius details amino acids 420 to 439 (20 residues), see Phobius details PF03553: Na_H_antiporter" amino acids 29 to 219 (191 residues), 47.4 bits, see alignment E=8.2e-17

Best Hits

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_1083)

Predicted SEED Role

"Methionine transporter MetT" in subsystem Methionine Biosynthesis or Methionine Degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (447 amino acids)

>CSW01_14950 sodium:proton antiporter (Vibrio cholerae E7946 ATCC 55056)
MHYTSSSKPQQPNAFALLPLMVFLLLFMGVGSYLTWQGVEFAFYQLPAPVAVLPAVVLAI
ALSKESLNRAIEQFLRGVGHSDIMAMCIIYLLAGAFAAVAKATGGVDATVNLGLALLPAS
LILPGLFVISAFVATAMGTSMGTIAAIAPVALGIAQAADLNLGLTAGVVLSGAMFGDNLS
IISDTTIAATRSQGCHMRDKFKENIRIALPAALLALVVFTFSSQTAQSPQTSDIEWLKVL
PYLTILVLAVMGLNVFLVLLVGILMAAGVGGLSDGYSLSALTKDVYAGFGNMQEIFLLSM
LIGGMGELMKQQGGLAFLTHHISRMIDKFARSHSDVQKMRASELGIAGLVALTNVCTANN
TVAIIVSGGVAKELAEHNGVTAKRSASLLDIFSCIMQGVLPYGAQALLLGSIFQMSPLSV
VSYSYYCFFLAVAALVAVFRRHTMRNA