Protein Info for CSW01_14895 in Vibrio cholerae E7946 ATCC 55056

Annotation: mechanosensitive ion channel family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 291 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 55 to 72 (18 residues), see Phobius details amino acids 78 to 102 (25 residues), see Phobius details PF00924: MS_channel_2nd" amino acids 100 to 170 (71 residues), 38.5 bits, see alignment E=5.1e-14

Best Hits

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_1094)

Predicted SEED Role

"Small-conductance mechanosensitive channel"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (291 amino acids)

>CSW01_14895 mechanosensitive ion channel family protein (Vibrio cholerae E7946 ATCC 55056)
MEHLSIAVDFLLTHKLLLTALILLGVISVRRLVLEHIRGDAALITEKQRKWMSRTKNGVF
TVTLLALFMLWQSEISEFALSVTAIAVAIVVASKEIILCFTGSIQRASSRSFRIGDWIEV
GSVCGEVIEHNLMATVIQEIDLHHGQYNYTGKTATLPNSMFFSHPVKNLNFMKRYVFHNF
KIVVPEFVNLFPLVPILHERIEGHFAHFMEVARRYNTVIERHAGVDLPSAEPHIEISSSS
TGEQVVHVMIFCPTERANQLEQLIRRDFMQEYERVFPRSTPTPIVPVPSAS