Protein Info for CSW01_14505 in Vibrio cholerae E7946 ATCC 55056

Annotation: nicotinate phosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01514: nicotinate phosphoribosyltransferase
  • amino acids 10 to 411 (402 residues), 623.3 bits, E=9.4e-192
• PF17767: NAPRTase_N
  • amino acids 15 to 138 (124 residues), 102.6 bits, E=2e-33
• PF04095: NAPRTase
  • amino acids 177 to 411 (235 residues), 314.6 bits, E=5.2e-98

Best Hits

Swiss-Prot: 100% identical to PNCB_VIBCM: Nicotinate phosphoribosyltransferase (pncB) from Vibrio cholerae serotype O1 (strain M66-2)

KEGG orthology group: K00763, nicotinate phosphoribosyltransferase [EC: 2.4.2.11] (inferred from 100% identity to vco:VC0395_0041)

Predicted SEED Role

"Nicotinate phosphoribosyltransferase (EC 2.4.2.11)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation or Redox-dependent regulation of nucleus processes (EC 2.4.2.11)

MetaCyc Pathways

• NAD salvage pathway I (PNC VI cycle) (5/7 steps found)
• NAD salvage pathway V (PNC V cycle) (3/5 steps found)
• NAD salvage (plants) (5/11 steps found)
• superpathway of NAD biosynthesis in eukaryotes (5/14 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Nicotinate and nicotinamide metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.11

Protein Sequence (435 amino acids)

>CSW01_14505 nicotinate phosphoribosyltransferase (Vibrio cholerae E7946 ATCC 55056)
MNPRLFSPHIIRSLLDLDAYKINMMQAIHHFYPDVSVRYELIVRSEEDASGLLDAIRQEI
AHLGTLRFSDADIHYLTQHAPHLKATFLQSLRYFHFVPQEQVEMGIVKQGGKQQLRISIR
GSWRDTILYETLVMAIVSEVRSRQRWAEVPADLPLKVLKTKLDQLKAEIERRGINNFSLT
EMGTRRRFSSQVQRDVLACLKQEIPQWVLGTSNYHFAREFDLKPIGTIAHEWFMGHQALV
NERDSQQVALERWLTAFDGMLAIAPTDTLTIDAFLNDFNRHLANAYDGVRHDSGCPFRWG
DKMIAHYQQLGIDPTTKLFIFSDGLDFDQALELCEYFAGRVKISFGIGTFLTNDLANWRN
AAGVEYRPLSIVIKLAECQGRPVAKISDQPEKAMCEDPIFLANLKRRFNIELDVDALIQE
LRHQKRSPRHYISAA