Protein Info for CSW01_14175 in Vibrio cholerae E7946 ATCC 55056

Annotation: Anion transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 462 transmembrane" amino acids 21 to 39 (19 residues), see Phobius details amino acids 45 to 61 (17 residues), see Phobius details amino acids 66 to 85 (20 residues), see Phobius details amino acids 92 to 111 (20 residues), see Phobius details amino acids 123 to 166 (44 residues), see Phobius details amino acids 178 to 200 (23 residues), see Phobius details amino acids 220 to 240 (21 residues), see Phobius details amino acids 261 to 279 (19 residues), see Phobius details amino acids 290 to 309 (20 residues), see Phobius details amino acids 318 to 336 (19 residues), see Phobius details amino acids 353 to 373 (21 residues), see Phobius details amino acids 380 to 398 (19 residues), see Phobius details amino acids 403 to 429 (27 residues), see Phobius details amino acids 441 to 461 (21 residues), see Phobius details PF00939: Na_sulph_symp" amino acids 25 to 462 (438 residues), 167.8 bits, see alignment E=4.6e-53 TIGR00785: transporter, divalent anion:Na+ symporter (DASS) family" amino acids 43 to 461 (419 residues), 375.1 bits, see alignment E=2.2e-116 PF03600: CitMHS" amino acids 57 to 404 (348 residues), 181.5 bits, see alignment E=2.5e-57

Best Hits

Swiss-Prot: 52% identical to Y608_HAEIN: Uncharacterized transporter HI_0608 (HI_0608) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K14445, solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 (inferred from 100% identity to vcj:VCD_000208)

MetaCyc: 100% identical to dicarboxylate:Na+ symporter (Vibrio cholerae O1 biovar El Tor str. N16961)
TRANS-RXN-500

Predicted SEED Role

"Di-and tricarboxylate transporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (462 amino acids)

>CSW01_14175 Anion transporter (Vibrio cholerae E7946 ATCC 55056)
MNRNDSVPLPTNTREWFLHRNSLIVLADVALFLALYHFLPFEHNVVLGISMLAFIAVLWL
TEALHVTVTAILVPVMAVFFGIFETQAALNNFANSIIFLFLGGFALAAAMHHQGLDKVIA
DKVLAMAQGKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDADKQRSTYVF
VLLGVAYSASIGGIATLVGSPPNAIAAAEVGLSFTDWMKFGLPTAMMMLPMAIAILYFLL
KPTLNGMFELDRAPVNWDKGKVVTLGIFGLTVFLWIFSSPINAALGGFKSFDTLVALGAI
LMLSFARVVHWKEIQKTADWGVLLLFGGGLCLSNVLKQTGTSVFLANALSDMVSHMGIFV
VILVVATFVVFLTEFASNTASAALLIPVFATVAEAFGMSPVLLSVLIAVAASCAFMLPVA
TPPNAIVFASGHIKQSEMMRVGLYLNIACIGLLTAIAMLFWQ