Protein Info for CSW01_13960 in Vibrio cholerae E7946 ATCC 55056

Annotation: potassium uptake protein TrkH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 485 transmembrane" amino acids 9 to 31 (23 residues), see Phobius details amino acids 37 to 57 (21 residues), see Phobius details amino acids 69 to 90 (22 residues), see Phobius details amino acids 105 to 120 (16 residues), see Phobius details amino acids 133 to 158 (26 residues), see Phobius details amino acids 184 to 208 (25 residues), see Phobius details amino acids 236 to 258 (23 residues), see Phobius details amino acids 276 to 295 (20 residues), see Phobius details amino acids 333 to 359 (27 residues), see Phobius details amino acids 398 to 419 (22 residues), see Phobius details amino acids 458 to 481 (24 residues), see Phobius details PF02386: TrkH" amino acids 39 to 478 (440 residues), 341.9 bits, see alignment E=2.8e-106 TIGR00933: potassium uptake protein, TrkH family" amino acids 84 to 468 (385 residues), 396 bits, see alignment E=1e-122

Best Hits

Swiss-Prot: 91% identical to TRKH_VIBPA: Trk system potassium uptake protein TrkH (trkH) from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

KEGG orthology group: K03498, trk system potassium uptake protein TrkH (inferred from 100% identity to vcj:VCD_001452)

MetaCyc: 69% identical to K+ transporter TrkH (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-3

Predicted SEED Role

"Potassium uptake protein TrkH" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (485 amino acids)

>CSW01_13960 potassium uptake protein TrkH (Vibrio cholerae E7946 ATCC 55056)
MQFRSIIRIVGLLLALFSVSMLAPALVALIYRDGAGVPFVSTFFVLLLCGGLFWFPNRHH
KHELKARDGFLIVVLFWTVIGSAGALPFLLAADPNISVTDAFFESFSALTTTGATVIVGL
DELPKAILFYRQFLQWFGGMGIIVLAVAILPVLGIGGMQLYRAEIPGPVKDTKVTPRIAE
TAKALWYIYLSLTIACASAFWLAGMSLFDAICHSFSTIAIGGFSTHDASMGYFDSYAINL
ITVVFLLISSCNFTLHYAAFATGGVHPKYYWRDPEFRAFFVIQVLLFVICFSVLLKHHSY
DSFYQAFDQALFQTVSISTTAGFTTTGFSDWPLFLPVLLLFSSFIGGCAGSTGGGMKVIR
VLLLTLQGAREMKRLVHPRAIYPIKLGGRALSQRVVDAVWGFFSAYALVFVVCMLALIAT
GMDELSAFSAVAATLNNLGPGLGEVAVHFADVNDKAKWILIASMLFGRLEIFTLLILLTP
TFWRS