Protein Info for CSW01_13690 in Vibrio cholerae E7946 ATCC 55056

Annotation: two-component system sensor histidine kinase EnvZ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 438 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 153 to 172 (20 residues), see Phobius details PF00672: HAMP" amino acids 170 to 221 (52 residues), 38.6 bits, see alignment 1.6e-13 PF00512: HisKA" amino acids 227 to 280 (54 residues), 46.3 bits, see alignment 5.6e-16 PF02518: HATPase_c" amino acids 326 to 434 (109 residues), 90.4 bits, see alignment E=1.6e-29

Best Hits

Swiss-Prot: 49% identical to ENVZ_SALTY: Osmolarity sensor protein EnvZ (envZ) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K07638, two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC: 2.7.13.3] (inferred from 99% identity to vco:VC0395_A2285)

MetaCyc: 50% identical to sensor histidine kinase EnvZ (Escherichia coli K-12 substr. MG1655)
Histidine kinase. [EC: 2.7.13.3]

Predicted SEED Role

"Osmolarity sensory histidine kinase EnvZ"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (438 amino acids)

>CSW01_13690 two-component system sensor histidine kinase EnvZ (Vibrio cholerae E7946 ATCC 55056)
MRIRSSFTQSILLFFSLLIASQIYSYYAVFNYALLPSLQQFNKILAHEISLMLDDTSNPN
VSSEMDALLKRRVLEQLGVTIHSNDSPEAVEYQHAISLDLMSEEMSSELGSPTEVRMALG
EESYILWMKIDSLPGQLLRIPLSELQEEDFAPLFRNSIIMALLIVIGGWLFIRLQNRPLI
ALEKAAKMVGRGETPPHLPEQGTLEIRSVTRAFNRMSKGIQALEEDRALLMAGISHDIRT
PLTRIRLATEMMSPEDSYLAESIISDTEECNQIISQFMDYLKPVNREAFEAVDLNDIASD
VASSEGGYEVQIETELQAGLAPALGNPIAIKRSLSNLVVNALRYGNGWVKVSSGMTADKK
LVWLSVEDNGPGIDPSQVNKVFEPFTRGDTARGSEGTGLGLAIVKRIVSQHHGAVSVSNR
SQGGLRAQISFPTKQQKG