Protein Info for CSW01_13645 in Vibrio cholerae E7946 ATCC 55056

Annotation: K+/H+ antiporter NhaP2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 581 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 30 to 47 (18 residues), see Phobius details amino acids 58 to 77 (20 residues), see Phobius details amino acids 88 to 114 (27 residues), see Phobius details amino acids 120 to 141 (22 residues), see Phobius details amino acids 165 to 179 (15 residues), see Phobius details amino acids 186 to 214 (29 residues), see Phobius details amino acids 226 to 257 (32 residues), see Phobius details amino acids 269 to 292 (24 residues), see Phobius details amino acids 300 to 323 (24 residues), see Phobius details amino acids 335 to 357 (23 residues), see Phobius details amino acids 364 to 384 (21 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 19 to 385 (367 residues), 201.8 bits, see alignment E=2.3e-63 PF02080: TrkA_C" amino acids 418 to 484 (67 residues), 47.8 bits, see alignment E=1.6e-16 PF03471: CorC_HlyC" amino acids 497 to 570 (74 residues), 31.4 bits, see alignment E=2.4e-11

Best Hits

Swiss-Prot: 100% identical to NHAP2_VIBCM: K(+)/H(+) antiporter NhaP2 (nhaP2) from Vibrio cholerae serotype O1 (strain M66-2)

KEGG orthology group: K11105, cell volume regulation protein A (inferred from 100% identity to vch:VC2703)

Predicted SEED Role

"K+/H+ antiporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (581 amino acids)

>CSW01_13645 K+/H+ antiporter NhaP2 (Vibrio cholerae E7946 ATCC 55056)
MDAVTINSFFMIGALLIGISVLLSPVSSKLGIPILLVFLAVGMLAGEDGIGQIAFDNYPV
AYLVSNLALAIILLDGGMRTRVASFRVAFWPSVSLATLGVAVTTLLTGLLAMWLFNLSLL
QGVLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGTNDPMAVFLTVTLIAVLGSAE
TNLSAGFLLLSFIQQFGVGALLGLAGGWILWWLINRNQLPEGLYSILAVSGGLMIFALSN
ALGGSGILSIYLTGLLLGNRPTRSRHAILNVLDGMTWLAQIGMFLVLGLLVTPSELMEIA
LPGLALAVGMILFARPIAVWIGLAPFKSFTAREKWFVSWVGLRGAVPIILAVFPMMAGLP
NAQLYFNLAFFVVMVSLVVQGGTLTKAMSLAKVELPPKPEPISRTGVEIYPTSEWELFIY
KLKADKWCIGEPLRNLFMPEGTRIAAVFRDNQLLHPSGSTELCEGDTLCVMAQERDLESL
SRLFSEAPEKASLARFFGDFFLDIEAKLQDVALLYGLDLGELEADAKLKDLVLEHLGETP
VLGDYFEWHGLQWVVADVVDWKVTKIGLRLPPEEELQEGAE