Protein Info for CSW01_13625 in Vibrio cholerae E7946 ATCC 55056

Annotation: C4-dicarboxylate ABC transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 435 transmembrane" amino acids 6 to 39 (34 residues), see Phobius details amino acids 47 to 70 (24 residues), see Phobius details amino acids 90 to 113 (24 residues), see Phobius details amino acids 133 to 161 (29 residues), see Phobius details amino acids 167 to 190 (24 residues), see Phobius details amino acids 228 to 251 (24 residues), see Phobius details amino acids 263 to 282 (20 residues), see Phobius details amino acids 293 to 313 (21 residues), see Phobius details amino acids 330 to 347 (18 residues), see Phobius details amino acids 359 to 383 (25 residues), see Phobius details amino acids 412 to 434 (23 residues), see Phobius details PF03605: DcuA_DcuB" amino acids 5 to 367 (363 residues), 488.1 bits, see alignment E=8.2e-151 TIGR00770: transporter, anaerobic C4-dicarboxylate uptake (Dcu) family" amino acids 5 to 434 (430 residues), 593.1 bits, see alignment E=1.8e-182

Best Hits

Swiss-Prot: 63% identical to DCUA_WOLSU: Anaerobic C4-dicarboxylate transporter DcuA (dcuA) from Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)

KEGG orthology group: K07791, anaerobic C4-dicarboxylate transporter DcuA (inferred from 100% identity to vco:VC0395_A2271)

MetaCyc: 57% identical to C4-dicarboxylate transporter DcuA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-106; TRANS-RXN-106A; TRANS-RXN-106B; TRANS-RXN-299; TRANS-RXN-379

Predicted SEED Role

"C4-dicarboxylate transporter DcuA"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (435 amino acids)

>CSW01_13625 C4-dicarboxylate ABC transporter (Vibrio cholerae E7946 ATCC 55056)
MIWVELAIVLLFIFIGARIGGIGIGLAGGAGVIALSLILGVPTKQAFIPVDVILIIMSVI
TAIAAMQVAGGMDWLVQLAENFLRKHPERITFYAPIVTFLMTLMAGTGHTAFSTLPVIAE
VAKGQGVRPSRPLSIAVVASQIAITASPISAAVVAFAAMLVPFGVDYLTLLAICIPTTFA
ACMVGAFVANFMGSELKDDPIYQERLAQGLIKLAGTQKREILPTAKTATYIFLTAIILVV
CYAAAISNSIGLIENPALGRNEAIMTFMLAAAAGIVLLTKIDAAQIPAASTFRSGMTACV
CVLGVAWLGSTFVNAHVDGIKEVAGTLLADYPWMLALVLFFASMLLYSQGATTVALMPAA
LAIGVAPLTAVASFAAVSALFVLPTYPTLLAAVEMDDTGSTRIGSYVFNHPFFIPGVVTI
ASAVAFGFLFGSLFI