Protein Info for CSW01_13510 in Vibrio cholerae E7946 ATCC 55056

Annotation: HslU--HslV peptidase ATPase subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 TIGR00390: ATP-dependent protease HslVU, ATPase subunit" amino acids 4 to 443 (440 residues), 731.7 bits, see alignment E=1.6e-224 PF07728: AAA_5" amino acids 52 to 89 (38 residues), 24 bits, see alignment 1.1e-08 PF00004: AAA" amino acids 53 to 101 (49 residues), 30.5 bits, see alignment 1.3e-10 amino acids 239 to 332 (94 residues), 29.6 bits, see alignment E=2.6e-10 PF07724: AAA_2" amino acids 185 to 329 (145 residues), 103.1 bits, see alignment E=5.2e-33

Best Hits

Swiss-Prot: 100% identical to HSLU_VIBCH: ATP-dependent protease ATPase subunit HslU (hslU) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K03667, ATP-dependent HslUV protease ATP-binding subunit HslU (inferred from 100% identity to vcm:VCM66_2594)

MetaCyc: 78% identical to ATPase component of the HslVU protease (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"ATP-dependent hsl protease ATP-binding subunit HslU" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (443 amino acids)

>CSW01_13510 HslU--HslV peptidase ATPase subunit (Vibrio cholerae E7946 ATCC 55056)
MSEMTPREIVSELNRHIIGQDKAKRAVAIALRNRWRRMQLEESLRVEVTPKNILMIGPTG
VGKTEIARRLAKLANVPFIKVEATKFTEVGYVGKEVESIIRDLTDVAVKLTHQQAMEKVK
FRAEELAEERVLDALLPPPRDAWGQAEQKEENSSTRQVFRKKLREGQLNDKEIEINVAVP
QMGVEIMAPPGMEEMTNQLQGLFQNLAGDTKKKRKMKIKDALKALVEEEAAKLVNQEELK
EQAIYNVENNGIVFIDEIDKICKRGEVSGPDVSREGVQRDLLPLIEGSTVSTKHGMVRTD
HILFIASGAFQVAKPSDLIPELQGRLPIRVELEALSSNDFKRILTEPKASLTEQYVALMK
TEQVDVQFTEDGIKQIADAAWQVNETTENIGARRLHTVLERLMDEISFDATEKAGQAFVI
DAAYVKARLGELVEDEDLSRFIL