Protein Info for CSW01_13495 in Vibrio cholerae E7946 ATCC 55056

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 460 transmembrane" amino acids 34 to 57 (24 residues), see Phobius details amino acids 64 to 64 (1 residues), see Phobius details amino acids 66 to 89 (24 residues), see Phobius details amino acids 109 to 134 (26 residues), see Phobius details amino acids 148 to 168 (21 residues), see Phobius details amino acids 180 to 199 (20 residues), see Phobius details amino acids 206 to 230 (25 residues), see Phobius details amino acids 269 to 289 (21 residues), see Phobius details amino acids 295 to 313 (19 residues), see Phobius details amino acids 327 to 354 (28 residues), see Phobius details amino acids 367 to 392 (26 residues), see Phobius details amino acids 403 to 422 (20 residues), see Phobius details amino acids 428 to 447 (20 residues), see Phobius details PF01554: MatE" amino acids 34 to 193 (160 residues), 93.9 bits, see alignment E=8.9e-31 amino acids 257 to 418 (162 residues), 68.1 bits, see alignment E=7.6e-23 TIGR00797: MATE efflux family protein" amino acids 34 to 423 (390 residues), 198.2 bits, see alignment E=1.1e-62 PF14667: Polysacc_synt_C" amino acids 148 to 252 (105 residues), 31.3 bits, see alignment E=2e-11

Best Hits

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_A2244)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (460 amino acids)

>CSW01_13495 MATE family efflux transporter (Vibrio cholerae E7946 ATCC 55056)
MLGTLFSFVAQLMHDKHGLLSAPIPLVLRQMTVPMIFGLVAILMFNLVDTFFISLLGTQA
LAAISYTFPVTFAVNCITMGIGVGLSTCIGRLLGQGDGRQAARVSSHGLLLALLLVAAAS
TLGLLTIEPLFLLLGASHELIPLIKEYMVVWYLTIPLLVLPMAGNSAIRATGDTKTPAKI
MMLAGLINGALDPLLIFGYGPFPELGIQGAAIASAFSWLGALIGSLYLLIKREKLLAIPS
LPHLRDDWQQILKIGTPAALSTAMNPISGALLMIMLSSHGTAAVAAYGATQRIESILILV
LMSLTSALTPFMAQNLGAQNPARSFAGLFLSLRFSLLFQLMVFIMMVPLSIPLAALFSQE
QAVRDLLWHYLLVVPVSYGFQGVVMMLVSALNALHQPLKAFQWSFMRLFVFTLPAAWIGG
RLYNIEGLFIGIAVGNILGGLLGYLYALRLRRQTLTPDLD