Protein Info for CSW01_13385 in Vibrio cholerae E7946 ATCC 55056

Annotation: acetylornithine deacetylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01892: acetylornithine deacetylase (ArgE)
  • amino acids 8 to 372 (365 residues), 410.1 bits, E=4.3e-127
• PF01546: Peptidase_M20
  • amino acids 72 to 374 (303 residues), 112.2 bits, E=3.4e-36
• PF07687: M20_dimer
  • amino acids 174 to 285 (112 residues), 87.7 bits, E=4.9e-29

Best Hits

Swiss-Prot: 100% identical to ARGE_VIBCM: Acetylornithine deacetylase (argE) from Vibrio cholerae serotype O1 (strain M66-2)

KEGG orthology group: K01438, acetylornithine deacetylase [EC: 3.5.1.16] (inferred from 100% identity to vcm:VCM66_2565)

MetaCyc: 56% identical to acetylornithine deacetylase (Escherichia coli K-12 substr. MG1655)
Acetylornithine deacetylase. [EC: 3.5.1.16]

Predicted SEED Role

"Acetylornithine deacetylase (EC 3.5.1.16)" in subsystem Arginine Biosynthesis extended (EC 3.5.1.16)

MetaCyc Pathways

• L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
• L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
• L-ornithine biosynthesis I (5/5 steps found)
• superpathway of arginine and polyamine biosynthesis (13/17 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.16

Protein Sequence (378 amino acids)

>CSW01_13385 acetylornithine deacetylase (Vibrio cholerae E7946 ATCC 55056)
MPLPSFLEVYEGLISTSSISSTDARWDEGNEQVIAKLADWLSALGFSIQIEQVAPNKQNL
IAKLGSGEGGLLLAGHSDTVPFDEGRWNYNPHALTQVNNRFYGLGTADMKGFFAFIYEAV
KNVDWSKQTKPLYVLATCDEETTMLGARHFTENAPFKPDYCIIGEPTSLVPIRAHKGHVA
NAIRVTGKSGHSSNPALGVNAIEIMHEVLFALMQLRDRLIKEYHHPGFEIPTPTLNLGHI
HGGDSPNRICGCCELHYDVRPLPGISLDGLDNLMHDALREVQQKWPGRIELVPLHDPIPG
YECAHDHPFIHGISEICEQEAQTVNYCTEAPFLQQVCPTLVLGPGSIDQAHQPDEFLAFE
FIDPTVRVLSRAMQKYCF