Protein Info for CSW01_13380 in Vibrio cholerae E7946 ATCC 55056

Annotation: N-acetyl-gamma-glutamyl-phosphate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01850: N-acetyl-gamma-glutamyl-phosphate reductase
  • amino acids 3 to 332 (330 residues), 398.5 bits, E=1.3e-123
• PF01113: DapB_N
  • amino acids 3 to 97 (95 residues), 25.4 bits, E=2.6e-09
• PF01118: Semialdhyde_dh
  • amino acids 4 to 145 (142 residues), 107.4 bits, E=1.3e-34
• PF22698: Semialdhyde_dhC_1
  • amino acids 154 to 307 (154 residues), 172.3 bits, E=1.6e-54
• PF02774: Semialdhyde_dhC
  • amino acids 164 to 310 (147 residues), 55.6 bits, E=1.6e-18

Best Hits

Swiss-Prot: 100% identical to ARGC_VIBCH: N-acetyl-gamma-glutamyl-phosphate reductase (argC) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K00145, N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase [EC: 1.2.1.- 1.2.1.38] (inferred from 100% identity to vcj:VCD_001719)

MetaCyc: 61% identical to N-acetylglutamylphosphate reductase (Escherichia coli K-12 substr. MG1655)
N-acetyl-gamma-glutamyl-phosphate reductase. [EC: 1.2.1.38]

Predicted SEED Role

"N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38)" in subsystem Arginine Biosynthesis extended (EC 1.2.1.38)

MetaCyc Pathways

• L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
• L-arginine biosynthesis II (acetyl cycle) (9/10 steps found)
• L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
• L-ornithine biosynthesis I (5/5 steps found)
• superpathway of arginine and polyamine biosynthesis (13/17 steps found)

KEGG Metabolic Maps

• 1- and 2-Methylnaphthalene degradation
• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Geraniol degradation
• Limonene and pinene degradation
• Lysine biosynthesis
• Naphthalene and anthracene degradation
• Tryptophan metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.-

Use Curated BLAST to search for 1.2.1.- or 1.2.1.38

Protein Sequence (333 amino acids)

>CSW01_13380 N-acetyl-gamma-glutamyl-phosphate reductase (Vibrio cholerae E7946 ATCC 55056)
MLKTTIIGASGYTGAELALMVHKHPQLTLSGLYVSANSVDAGKSLAQLHGRVAGLIDMPV
QALTDVDTVAAECDVVFLATAHEVSHDLAPQFLAQGCQVFDLSGAFRVQSEAFYPTFYGF
AHQHSEWLEKAVYGLAEWNAEAIKTSPMIAVAGCYPTASQLAIKPLLVDGLIDTTQWPVI
NAVSGVSGAGRKATMTNSFCEVSLQPYGVFNHRHQPEIATHLGCEVIFTPHLGNFKRGIL
ATITMKLADGVTEQQVAEAFSKAYQDKPLVRFSNGLPRIQDVEFTPFCDLGWKVQGRHII
VVSAIDNLLKGASSQAMQCLNIHYGFDELTALV