Protein Info for CSW01_13280 in Vibrio cholerae E7946 ATCC 55056

Annotation: phosphoglycolate phosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 226 PF00702: Hydrolase" amino acids 4 to 187 (184 residues), 109.1 bits, see alignment E=1.2e-34 TIGR01449: phosphoglycolate phosphatase, bacterial" amino acids 7 to 220 (214 residues), 198.3 bits, see alignment E=2.3e-62 PF13419: HAD_2" amino acids 7 to 191 (185 residues), 135.8 bits, see alignment E=5.5e-43 PF12710: HAD" amino acids 7 to 184 (178 residues), 45.6 bits, see alignment E=3.4e-15 TIGR01509: HAD hydrolase, family IA, variant 3" amino acids 74 to 192 (119 residues), 44.9 bits, see alignment E=2.7e-15 TIGR01662: HAD hydrolase, family IIIA" amino acids 88 to 190 (103 residues), 46.7 bits, see alignment E=6.9e-16 TIGR01549: HAD hydrolase, family IA, variant 1" amino acids 108 to 187 (80 residues), 35.6 bits, see alignment E=2.4e-12 PF05116: S6PP" amino acids 127 to 180 (54 residues), 21.3 bits, see alignment E=5.4e-08 PF13242: Hydrolase_like" amino acids 149 to 217 (69 residues), 47.7 bits, see alignment E=3.6e-16

Best Hits

Swiss-Prot: 100% identical to GPH_VIBCH: Phosphoglycolate phosphatase (gph) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K01091, phosphoglycolate phosphatase [EC: 3.1.3.18] (inferred from 100% identity to vco:VC0395_A2201)

Predicted SEED Role

"Phosphoglycolate phosphatase (EC 3.1.3.18)" in subsystem 2-phosphoglycolate salvage or Glycolate, glyoxylate interconversions or Photorespiration (oxidative C2 cycle) (EC 3.1.3.18)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.3.18

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (226 amino acids)

>CSW01_13280 phosphoglycolate phosphatase (Vibrio cholerae E7946 ATCC 55056)
MKSIKLIAFDLDGTLLDSVPDLAVAADQAARAVGYPAVSEAQVRDYVGNGADVLIARALS
QSLTINPELSPELRAQARHLFDEFYEQTGHKLSHLYPNVKTTLLELHQAGFILALVTNKP
SKFVPDVLEQHGIAHFFSDVIGGDTFPNKKPDPMALNWLLEKHQLSAEQMLMVGDSKNDI
LAAKNAGCYSFGLTYGYNHGEPIANAEPDFVSDDIGTLLEVVLVSA