Protein Info for CSW01_13240 in Vibrio cholerae E7946 ATCC 55056

Annotation: N-succinylglutamate 5-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 485 TIGR03240: succinylglutamate-semialdehyde dehydrogenase" amino acids 3 to 484 (482 residues), 745 bits, see alignment E=1.8e-228 PF00171: Aldedh" amino acids 9 to 456 (448 residues), 402.4 bits, see alignment E=1.2e-124

Best Hits

Swiss-Prot: 100% identical to ASTD_VIBC3: N-succinylglutamate 5-semialdehyde dehydrogenase (astD) from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

KEGG orthology group: K06447, succinylglutamic semialdehyde dehydrogenase [EC: 1.2.1.71] (inferred from 100% identity to vco:VC0395_A2193)

MetaCyc: 57% identical to aldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Succinylglutamate-semialdehyde dehydrogenase. [EC: 1.2.1.71]

Predicted SEED Role

"Succinylglutamic semialdehyde dehydrogenase (EC 1.2.1.71)" in subsystem Arginine and Ornithine Degradation (EC 1.2.1.71)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.71

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (485 amino acids)

>CSW01_13240 N-succinylglutamate 5-semialdehyde dehydrogenase (Vibrio cholerae E7946 ATCC 55056)
MTHWIAGEWVAGTGEKLESHTPYSHELLWQGYSASGEQVDAAVKAARRAFLDWKKRPFAE
REQKVLAFAELVKANSEQIAQVIAKETGKPLWETRTEAASIAGKIAISIRAYHERTGETV
REAAGNQLVLRHRPLGVMAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSEQTPWTGEVL
MQLWQQAGLPAGVINLVQGSKETGIALAQSRGIDGLLFTGSANTGHLLHRQFAGQPDKML
ALEMGGNNPMVISEHYGDLDATVYTIIQSAFISSGQRCTCVRRLYVPQGTKGDALLDKLV
SVTAKLRIDQPFAEPAPFMGPLVSEAAAQAILKAQADLQALGGKSLLEARALHAAFITPA
IIDVTAIERLPDDEYFGPLLQVVRYQTLAQAVELANDTRFGLSAGLVSTDDGEWDYFVEH
IRAGIVNRNRQLTGASGDAPFGGPGASGNLRPSAFYAADYCAYPMASMEGDTTLLPATLS
PGVEL