Protein Info for CSW01_13195 in Vibrio cholerae E7946 ATCC 55056

Annotation: glutathione-regulated potassium-efflux system protein KefB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 33 to 52 (20 residues), see Phobius details amino acids 58 to 77 (20 residues), see Phobius details amino acids 89 to 111 (23 residues), see Phobius details amino acids 117 to 137 (21 residues), see Phobius details amino acids 150 to 172 (23 residues), see Phobius details amino acids 183 to 201 (19 residues), see Phobius details amino acids 213 to 231 (19 residues), see Phobius details amino acids 237 to 256 (20 residues), see Phobius details amino acids 268 to 288 (21 residues), see Phobius details amino acids 294 to 313 (20 residues), see Phobius details amino acids 326 to 346 (21 residues), see Phobius details amino acids 355 to 374 (20 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 17 to 372 (356 residues), 203.3 bits, see alignment E=5.7e-64 TIGR00932: transporter, monovalent cation:proton antiporter-2 (CPA2) family" amino acids 17 to 283 (267 residues), 271.7 bits, see alignment E=3.9e-85 PF02254: TrkA_N" amino acids 402 to 512 (111 residues), 90.7 bits, see alignment E=8.5e-30

Best Hits

Swiss-Prot: 60% identical to KEFB_YERPS: Glutathione-regulated potassium-efflux system protein KefB (kefB) from Yersinia pseudotuberculosis serotype I (strain IP32953)

KEGG orthology group: K11747, glutathione-regulated potassium-efflux system protein KefB (inferred from 100% identity to vch:VC2606)

MetaCyc: 58% identical to K+ : H+ antiporter KefB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-42

Predicted SEED Role

"Glutathione-regulated potassium-efflux system protein KefB" in subsystem Glutathione-regulated potassium-efflux system and associated functions

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (600 amino acids)

>CSW01_13195 glutathione-regulated potassium-efflux system protein KefB (Vibrio cholerae E7946 ATCC 55056)
MTPLTSDFLSSSVVFLSAAVIAVPLAQRAGLGSVLGYLLAGIAIGPWGLGLIRDVQAIMH
FAEFGVVLLLFLIGLELNPKKLWNLRGPILGLGGAQVVVTTAVLSSVAYLLGVSWQSALV
IGMALALSSTAIALRVIEEHGLTRTEAGQSGFAVLLFQDIAVIPMLALLPILAGNSSGDW
LNALWMTGGIAALLLGGHFLLNPLFRYIALSGVRELFTVAALLLVVGIALLMQKVGLSMA
LGTFLAGVILAESEFRHELEIAIDPFKGLLLGLFFISVGMAVDVGLLLVKPLQIMLAVLG
LVIVKGLVLYLLARLSGTVAKARSKMAAILSQGGEFAFVIFTAASAEGLLTASQVSFLLV
VVSLSMVTTPLLLSAQKYWFARQLNIEENPLTPDVENKEPRVIIVGFGRFGQIVGRLLYA
NKIKVTILESDASQVRLLRKYGYKVFYGDATNLELLRAAGVEQAEALVVCTDDPEQVITI
VELCQQHFPNLKLLARARSRVEAYQLMSLGVQNYTRETFLSALDLGRKALVQLGMHPYQA
KRAEEHFHRLDKTMLKELLPQHNEDKQLELRAKEARTELEEIFSREMDSDQLSRRYWEKE