Protein Info for CSW01_13180 in Vibrio cholerae E7946 ATCC 55056

Annotation: isoaspartyl peptidase/L-asparaginase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 326 PF01112: Asparaginase_2" amino acids 6 to 320 (315 residues), 356.9 bits, see alignment E=4.4e-111

Best Hits

Swiss-Prot: 40% identical to ASPG_LUPAR: Isoaspartyl peptidase/L-asparaginase (Fragment) from Lupinus arboreus

KEGG orthology group: K13051, beta-aspartyl-peptidase (threonine type) [EC: 3.4.19.5] (inferred from 100% identity to vch:VC2603)

Predicted SEED Role

"Isoaspartyl aminopeptidase (EC 3.4.19.5) @ Asp-X dipeptidase" (EC 3.4.19.5)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.19.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (326 amino acids)

>CSW01_13180 isoaspartyl peptidase/L-asparaginase (Vibrio cholerae E7946 ATCC 55056)
MTQPFAIAIHGGAGTILREQMSDALRMDILATLEQAVRAGHQLLVEGADALDAVVAAVTV
LEDSPLFNAGKGSVLTHNEMVEMDASVMHGAAREAGAIAGVRHIRNPIQLARDVLRHSDH
VFLIGDGAEQFAFQQGHVYTEQDYFFTERRYEQLQNMKQQDRFALSEASYQSESAEQESP
SEYPDDKKFGTVGAVALDQQGNLAAATSTGGITNKRFGRVGDSPIIGAGTLAENGNVAIS
CTGMGEYFIRYAVAGDIAARMRYLKEDVHTACETVVQGELKSVGGEGGLIAIDAQGELHF
AMNSSGMYRAGIDRDGQFSVKIYADE