Protein Info for CSW01_12860 in Vibrio cholerae E7946 ATCC 55056

Annotation: thiamine/thiamine pyrophosphate ABC transporter permease ThiP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 530 transmembrane" amino acids 7 to 29 (23 residues), see Phobius details amino acids 51 to 73 (23 residues), see Phobius details amino acids 84 to 107 (24 residues), see Phobius details amino acids 126 to 145 (20 residues), see Phobius details amino acids 191 to 212 (22 residues), see Phobius details amino acids 232 to 253 (22 residues), see Phobius details amino acids 285 to 307 (23 residues), see Phobius details amino acids 327 to 347 (21 residues), see Phobius details amino acids 367 to 387 (21 residues), see Phobius details amino acids 396 to 414 (19 residues), see Phobius details amino acids 458 to 477 (20 residues), see Phobius details amino acids 499 to 518 (20 residues), see Phobius details TIGR01253: thiamine/thiamine pyrophosphate ABC transporter, permease protein" amino acids 11 to 517 (507 residues), 541.7 bits, see alignment E=1.2e-166 PF00528: BPD_transp_1" amino acids 64 to 259 (196 residues), 31.4 bits, see alignment E=7.7e-12 amino acids 361 to 516 (156 residues), 29.2 bits, see alignment E=3.7e-11

Best Hits

KEGG orthology group: K02063, thiamine transport system permease protein (inferred from 100% identity to vcm:VCM66_2459)

Predicted SEED Role

"Thiamin ABC transporter, transmembrane component" in subsystem Thiamin biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (530 amino acids)

>CSW01_12860 thiamine/thiamine pyrophosphate ABC transporter permease ThiP (Vibrio cholerae E7946 ATCC 55056)
MNRTPQLGFWVAAGVATFVLAALAALLWQSPPFNLNLIWQDAYYRHVTQFSFYQAFWSTV
LSVGLAIPVAHALSQRRFPGRDLLLKLFAMTLVLPVLVAIFGLIAIYGNSGFLAKTLHSV
GFPLPFSIYGLNGILLAHVLFNLPYASRLLLQSLEAIPSEQHKLCAHLGMSRWQKFKWVE
WPRLRQQLPHVAGLVFMLCFTSFATVMALGGGPKATTIELAIYQAIKFDFDLQIGALLAI
WQMLLCTLLTFTLQRFSHSRPMNSAASKVTERWVRDSWRAKVWDASWIVAACVLVLPPLV
MVVLAGLNSKLGKVLTSGDFWSAVSHSLQVASLASSLALASGIAMLLTSRALRLKAAHRR
ANGVEWIATLILVTPGLVVSTGLFLLLRNITDVFRLAYWIVVAVNALMALPYVVKTLSQP
MWHLAQQYELLCASLGMSGWRRFRLVEWRALRKPLSHAFAIGFLLSMGDLSAIALFGSQD
FRTLPLYLYQLLGSYQMDTAAVVALAMLIMSVGWFYVIERLFAQRPLTKC