Protein Info for CSW01_12795 in Vibrio cholerae E7946 ATCC 55056

Annotation: 3-deoxy-manno-octulosonate-8-phosphatase KdsC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 185 TIGR01670: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family" amino acids 23 to 175 (153 residues), 208 bits, see alignment E=3.4e-66 PF13419: HAD_2" amino acids 59 to 138 (80 residues), 25.7 bits, see alignment E=1.2e-09 PF08282: Hydrolase_3" amino acids 92 to 157 (66 residues), 32.8 bits, see alignment E=6.1e-12

Best Hits

Swiss-Prot: 61% identical to KDSC_SALTY: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC (kdsC) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03270, 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC: 3.1.3.45] (inferred from 100% identity to vco:VC0395_A2105)

MetaCyc: 60% identical to 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase monomer (Escherichia coli BL21(DE3))
3-deoxy-manno-octulosonate-8-phosphatase. [EC: 3.1.3.45]

Predicted SEED Role

"3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (EC 3.1.3.45)" in subsystem KDO2-Lipid A biosynthesis (EC 3.1.3.45)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.3.45

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (185 amino acids)

>CSW01_12795 3-deoxy-manno-octulosonate-8-phosphatase KdsC (Vibrio cholerae E7946 ATCC 55056)
MSSTVSTLYGEVEPSLLEIAKQIKLLICDVDGVFSDGLIYMGNQGEELKTFHTRDGYGVK
ALMNAGIEIAIITGRRSQIVENRMKALGISLIYQGQDDKVQAYYDICQKLAIAPEQTGYI
GDDLIDWPVMEKVALRVCVADGHPLLAQRANYVTHIKGGHGAVREVCDLILQARNELDVH
KGLSL