Protein Info for CSW01_12790 in Vibrio cholerae E7946 ATCC 55056

Annotation: KpsF/GutQ family sugar-phosphate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 326 PF01380: SIS" amino acids 45 to 175 (131 residues), 110.4 bits, see alignment E=5.6e-36 TIGR00393: sugar isomerase, KpsF/GutQ family" amino acids 48 to 316 (269 residues), 385.7 bits, see alignment E=6.2e-120 PF00571: CBS" amino acids 206 to 260 (55 residues), 24.8 bits, see alignment E=2.3e-09 amino acids 271 to 323 (53 residues), 31.5 bits, see alignment 1.8e-11

Best Hits

Swiss-Prot: 66% identical to KDSD_YERPE: Arabinose 5-phosphate isomerase KdsD (kdsD) from Yersinia pestis

KEGG orthology group: K06041, arabinose-5-phosphate isomerase [EC: 5.3.1.13] (inferred from 100% identity to vco:VC0395_A2104)

MetaCyc: 63% identical to D-arabinose 5-phosphate isomerase KdsD (Escherichia coli K-12 substr. MG1655)
Arabinose-5-phosphate isomerase. [EC: 5.3.1.13]

Predicted SEED Role

"Arabinose 5-phosphate isomerase (EC 5.3.1.13)" in subsystem KDO2-Lipid A biosynthesis (EC 5.3.1.13)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (326 amino acids)

>CSW01_12790 KpsF/GutQ family sugar-phosphate isomerase (Vibrio cholerae E7946 ATCC 55056)
MRMPHSFDYQTVAKQVLATEIHALQQLEQYINDDFARACAMILANQTGKVVVMGMGKSGH
IGKKIAATLASTGTSAFFVHPGEASHGDLGMIERGDIVLAISNSGESSEILALLPVLKRL
SIRVISMTGNPNSNMAKLADIHLQITVPREACPLELAPTSSTTATLVMGDALAVALMQAR
GFTAEDFALSHPGGALGRKLLLKLNDIMHSGDALPKVAPQALIRDALLEISQKGLGMTAI
VDEQDTLLGIFTDGDLRRILDKRIDIHSTVIADVMTRQPTVAQPNLLAVEGLNLMQAKRI
NGLMLVENNKLVGALNMHDLLKAGVM