Protein Info for CSW01_12760 in Vibrio cholerae E7946 ATCC 55056

Annotation: phospholipid-binding protein MlaC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 213 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF05494: MlaC" amino acids 35 to 200 (166 residues), 154.3 bits, see alignment E=1.3e-49

Best Hits

Swiss-Prot: 39% identical to MLAC_SHIFL: Intermembrane phospholipid transport system binding protein MlaC (mlaC) from Shigella flexneri

KEGG orthology group: K07323, putative toluene tolerance protein (inferred from 100% identity to vco:VC0395_A2099)

Predicted SEED Role

"Uncharacterized ABC transporter, auxiliary component YrbC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (213 amino acids)

>CSW01_12760 phospholipid-binding protein MlaC (Vibrio cholerae E7946 ATCC 55056)
MMWKKALLLASTLLMPWLATAATIDTSNPYQMMKAVAEKSFDRLKNEQPKVHQDPQYLKV
IVEEELMPYVNEQYAALKLLGPNLKGAKREDVAEFVKAFRAYLVTNYAQVLTQYTNQTIE
FGPEMPLEEDRRITTVKVEILDAPRPNIKLEFKLRQEKSGEWKAFDMIAEGISLLSSKQS
EWSGKIRQEGILAVAKELEQLANQPIRFESQKQ