Protein Info for CSW01_12740 in Vibrio cholerae E7946 ATCC 55056

Annotation: 1-acyl-sn-glycerol-3-phosphate acyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00530: 1-acylglycerol-3-phosphate O-acyltransferases
  • amino acids 69 to 199 (131 residues), 148.6 bits, E=4.2e-48
• PF01553: Acyltransferase
  • amino acids 73 to 199 (127 residues), 121.8 bits, E=8.9e-40

Best Hits

Swiss-Prot: 59% identical to PLSC_ECOLI: 1-acyl-sn-glycerol-3-phosphate acyltransferase (plsC) from Escherichia coli (strain K12)

KEGG orthology group: K00655, 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC: 2.3.1.51] (inferred from 100% identity to vch:VC2513)

MetaCyc: 59% identical to 1-acylglycerol-3-phosphate O-acyltransferase PlsC (Escherichia coli K-12 substr. MG1655)
1-acylglycerol-3-phosphate O-acyltransferase. [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]

Predicted SEED Role

"1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Phosphate metabolism (EC 2.3.1.51)

MetaCyc Pathways

• phosphatidylglycerol biosynthesis I (6/6 steps found)
• phosphatidylglycerol biosynthesis II (6/6 steps found)
• superpathway of phospholipid biosynthesis III (E. coli) (10/12 steps found)
• CDP-diacylglycerol biosynthesis I (4/4 steps found)
• CDP-diacylglycerol biosynthesis II (4/4 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (10/13 steps found)
• CDP-diacylglycerol biosynthesis III (4/5 steps found)
• oleate biosynthesis III (cyanobacteria) (2/3 steps found)
• palmitoleate biosynthesis III (cyanobacteria) (1/2 steps found)
• phospholipid remodeling (phosphatidate, yeast) (1/2 steps found)
• phosphatidate biosynthesis (yeast) (3/5 steps found)
• diacylglycerol and triacylglycerol biosynthesis (3/7 steps found)
• palmitoyl ethanolamide biosynthesis (2/6 steps found)
• superpathway of stearidonate biosynthesis (cyanobacteria) (2/6 steps found)
• stigma estolide biosynthesis (2/7 steps found)
• anandamide biosynthesis II (2/8 steps found)
• anandamide biosynthesis I (3/12 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)
• plasmalogen biosynthesis I (aerobic) (1/16 steps found)

KEGG Metabolic Maps

• Glycerolipid metabolism
• Glycerophospholipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.51

Use Curated BLAST to search for 2.3.1.51

Protein Sequence (261 amino acids)

>CSW01_12740 1-acyl-sn-glycerol-3-phosphate acyltransferase (Vibrio cholerae E7946 ATCC 55056)
MGRNPRVSAFFFQCLRRSCMIALLRILAVAVFAVYMFVFGCGYCLFSPRNPKHVYTFGKQ
FAAMSKVFGIKLEYRAPADVDQRGQHIYIANHQNNWDLFTVSKAVTPKVVTVGKKSLAWM
PLFGQLYWLTGNILIDRANKAKAKGTIDQVVDSMKQSDVSVWMFPEGTRSRGRGLLPFKA
GAFHAAIGAGVPIIPIVCSSTDKLKFNRWNNGHVIVEVLPPISTEGYSKENIRELSQHCY
DLMKAKLAQLDAEVAELNRKA