Protein Info for CSW01_12405 in Vibrio cholerae E7946 ATCC 55056

Annotation: GTP diphosphokinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 738 PF13328: HD_4" amino acids 51 to 190 (140 residues), 136.9 bits, see alignment E=1.2e-43 TIGR00691: RelA/SpoT family protein" amino acids 64 to 736 (673 residues), 616.1 bits, see alignment E=3.9e-189 PF04607: RelA_SpoT" amino acids 250 to 359 (110 residues), 143.9 bits, see alignment E=6e-46 PF02824: TGS" amino acids 403 to 462 (60 residues), 82 bits, see alignment 6.3e-27 PF19296: RelA_AH_RIS" amino acids 480 to 640 (161 residues), 49.1 bits, see alignment E=1.8e-16 PF13291: ACT_4" amino acids 660 to 736 (77 residues), 60.9 bits, see alignment E=3.9e-20

Best Hits

Swiss-Prot: 75% identical to RELA_PHOAS: GTP pyrophosphokinase (relA) from Photobacterium angustum (strain S14 / CCUG 15956)

KEGG orthology group: K00951, GTP pyrophosphokinase [EC: 2.7.6.5] (inferred from 100% identity to vcj:VCD_001903)

MetaCyc: 67% identical to GDP/GTP pyrophosphokinase (Escherichia coli K-12 substr. MG1655)
GTP diphosphokinase. [EC: 2.7.6.5]; 2.7.6.5 [EC: 2.7.6.5]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.6.5

Use Curated BLAST to search for 2.7.6.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (738 amino acids)

>CSW01_12405 GTP diphosphokinase (Vibrio cholerae E7946 ATCC 55056)
MVAVRSAHLNPDQQFELETWIASLTQEGKTAAKLTAVYRDCEQLLAGNPQGPLLLWRGRE
MIEILITLSMDRPTLVAALLFPIATSGVLDNESLEEGYGREVVKLIHGVEEMAAIGQLNV
TMHGSEASAQVDNVRRMLLAMVDDFRCVVIKLAERICNLREVKNEPDEVRRVAAKECANI
YAPLANRLGIGQLKWEIEDYAFRYQQPDTYKQIAKQLSERRIVREQYIRDFVSDLRAEMK
QSGINAEVSGRPKHIYSIWRKMQKKSLAFDELFDVRAVRIIADKLQDCYAALGIVHTKYK
HLPNEFDDYVANPKPNGYQSIHTVILGPEGKTIEIQIRTKQMHEESELGVAAHWKYKEGS
SAARSGYDEKITWLRKLLDWQEEMSDSGEMLDELRSQVFDDRVYAFTPKGDVVDLPMGAT
PLDFAYHIHSEVGHRCIGAKVAGRIVPFTHKLQMGDQVEIITAKEPNPSRDWLNPSLGFV
HSGRARAKINAWFRKQSREKNLEAGREILEIELAKIGANLKHAEAYALKRFNVNSVDEMY
VGIGSGDLRINQIVNHINALVNKPTAEEEDKLALEKLQENKTLTPNRPHKDAVVVEGVDN
LMTHLARCCQPIPGDEIRGYITQGRGISVHRSDCEQLEELSLHAPERIIDTVWGSGFVGS
YLLTVRVEAMERSGLLKDITTLLANEKVKVASMKSRSDYKRQIIIMDFDLEVNNVEALAR
VSKRIEQIKDVMLVKRLG