Protein Info for CSW01_12395 in Vibrio cholerae E7946 ATCC 55056

Annotation: CTP synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00337: CTP synthase
  • amino acids 2 to 535 (534 residues), 861.4 bits, E=1.2e-263
• PF06418: CTP_synth_N
  • amino acids 5 to 265 (261 residues), 421.7 bits, E=1.7e-130
• PF00117: GATase
  • amino acids 301 to 534 (234 residues), 154 bits, E=5.9e-49

Best Hits

Swiss-Prot: 100% identical to PYRG_VIBCH: CTP synthase (pyrG) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K01937, CTP synthase [EC: 6.3.4.2] (inferred from 100% identity to vcm:VCM66_2371)

MetaCyc: 79% identical to CTP synthetase (Escherichia coli K-12 substr. MG1655)
CTP synthase. [EC: 6.3.4.2]

Predicted SEED Role

"CTP synthase (EC 6.3.4.2)" (EC 6.3.4.2)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• superpathway of pyrimidine ribonucleosides salvage (9/10 steps found)
• superpathway of pyrimidine nucleobases salvage (4/4 steps found)
• UTP and CTP de novo biosynthesis (3/3 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• L-glutamine degradation I (1/1 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• L-glutamate and L-glutamine biosynthesis (5/7 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• UTP and CTP dephosphorylation II (1/3 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (1/4 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (1/4 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.2

Protein Sequence (545 amino acids)

>CSW01_12395 CTP synthetase (Vibrio cholerae E7946 ATCC 55056)
MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLKVTMMKLDPYINVDPGTMSPTQHGEV
FVTEDGAETDLDLGHYERFIRTKMTKRNNFTAGRVYADVLRKERRGDYLGATIQVIPHIT
NAIKDRVIAGSEGHDIAIVEVGGTVGDIESLPFMEAIRQLAIEVGREHAMFMHLTLVPYL
AAAGEVKTKPTQHSVKELLSIGIQPDILVCRSDRMIPANERKKIALFCNVPEKAVISMKD
VDSIYKIPQLIRSQGLDDLVCARFGINAPEADLSEWEQVIYEEANPTGEVTIGMVGKYTE
LPDAYKSVNEALKHAGLKNRLSVTIKYVDSQDVETKGTDVLNGLDAILVPGGFGDRGIEG
KIRAAQYARENKIPYLGICLGMQVALIEYARNVAGMEGAHSTEFNKNTKYPVVGLITEWV
DGEGNVEERSEKSDLGGTMRLGSQLCHLEKGTKAYELYGSATIHERHRHRYEVNNLLRPQ
IEKAGLKVSGLSADKKLVEVIENPAHPWFVAAQFHPEFTSTPRDGHPLFAGFVKAAGQFQ
RGELK