Protein Info for CSW01_12370 in Vibrio cholerae E7946 ATCC 55056

Annotation: SH3 domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 202 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 169 to 188 (20 residues), see Phobius details TIGR04211: SH3 domain protein" amino acids 23 to 201 (179 residues), 168.7 bits, see alignment E=5.9e-54 PF08239: SH3_3" amino acids 31 to 81 (51 residues), 35.3 bits, see alignment E=5.2e-13

Best Hits

Swiss-Prot: 32% identical to YGIM_ECO57: Uncharacterized protein YgiM (ygiM) from Escherichia coli O157:H7

KEGG orthology group: K07184, SH3 domain protein (inferred from 100% identity to vcm:VCM66_2366)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (202 amino acids)

>CSW01_12370 SH3 domain-containing protein (Vibrio cholerae E7946 ATCC 55056)
MKKLICMVLFSMLAAPTFAQDRYIADKLFTYMHSGPSNQYRILGSIDAGEKVKLIEVNKE
SGYSHIADERGRTGWVESRFITREVSNTLRLPALEKELEEVKKLLANARQNADSEKAGLA
ESLELRNQQIADLERNYADISKQLTDSQSEIRELRAKLDTQKEDLLLKYFTYGGGVAGIG
LLLGLVLPHIIPRRKRHPAGWA