Protein Info for CSW01_12280 in Vibrio cholerae E7946 ATCC 55056

Annotation: type IV pilin assembly protein PilC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 408 transmembrane" amino acids 172 to 195 (24 residues), see Phobius details amino acids 225 to 244 (20 residues), see Phobius details amino acids 380 to 401 (22 residues), see Phobius details PF00482: T2SSF" amino acids 74 to 196 (123 residues), 115.4 bits, see alignment E=8.3e-38 amino acids 277 to 399 (123 residues), 97.9 bits, see alignment E=2.2e-32

Best Hits

Swiss-Prot: 100% identical to PILC_VIBCH: Type IV pilin assembly protein PilC (pilC) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K02653, type IV pilus assembly protein PilC (inferred from 100% identity to vcj:VCD_001930)

Predicted SEED Role

"Type IV fimbrial assembly protein PilC" in subsystem Type IV pilus

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (408 amino acids)

>CSW01_12280 type IV pilin assembly protein PilC (Vibrio cholerae E7946 ATCC 55056)
MKATQTLPLKNYRWKGINSNGKKVSGQMLAISEIEVRDKLKDQHIQIKKLKKGSVSLLAR
LTHRVKSKDITILTRQLATMLTTGVPIVQALKLVGDNHRKAEMKSILAQITKSVEAGTPL
SKAMRTASAHFDTLYVDLVETGEMSGNLPEVFERLATYREKSEQLRAKVIKALIYPSMVV
LVALGVSYLMLTMVIPEFESMFKGFGAELPWFTQQVLKLSHWVQAYSLWAFIAIAAAIFG
LKALRKNSFQIRLKTSRLGLKFPIIGNVLAKASIAKFSRTLATSFAAGIPILASLKTTAK
TSGNVHFETAINEVYRDTAAGMPMYIAMRNTEAFPEMVLQMVMIGEESGQLDDMLNKVAT
IYEFEVDNTVDNLGKILEPLIIVFLGTVVGGLVVAMYLPIFNLMSVLG