Protein Info for CSW01_12010 in Vibrio cholerae E7946 ATCC 55056

Annotation: GGDEF domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 579 transmembrane" amino acids 8 to 29 (22 residues), see Phobius details amino acids 60 to 74 (15 residues), see Phobius details PF13188: PAS_8" amino acids 40 to 74 (35 residues), 18.7 bits, see alignment (E = 3.3e-07) TIGR00229: PAS domain S-box protein" amino acids 274 to 399 (126 residues), 54.1 bits, see alignment E=1.7e-18 PF00989: PAS" amino acids 279 to 389 (111 residues), 39.8 bits, see alignment E=1.1e-13 PF08448: PAS_4" amino acids 283 to 393 (111 residues), 61.1 bits, see alignment E=2.8e-20 PF13426: PAS_9" amino acids 288 to 391 (104 residues), 26.6 bits, see alignment E=1.5e-09 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 406 to 573 (168 residues), 159.1 bits, see alignment E=7.9e-51 PF00990: GGDEF" amino acids 411 to 571 (161 residues), 169.7 bits, see alignment E=1.1e-53

Best Hits

KEGG orthology group: K02488, two-component system, cell cycle response regulator (inferred from 100% identity to vcm:VCM66_2293)

Predicted SEED Role

"Sensory box/GGDEF family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (579 amino acids)

>CSW01_12010 GGDEF domain-containing protein (Vibrio cholerae E7946 ATCC 55056)
MPEFLSEFVRFLFAAGLVLGGGLWLFSGWQRYVQPQQWIQLLHHAPSGMLLVGEDRVLRA
NLAAYLLLGIRLVGRHYLFSAEQSEESQQAFYRALASSAQQKRSVPLLWPVPGNLTQTLE
ISASLLRRWPKKLWLVNVIGFECPSHDIQQERHSLAIARTALDSLSELIFIKSTEGHLIA
TNRAFDQFWQGRIEEGSATFKGIMKGRTSQRCWTVTPDGRSCLLETYQRVLMSPQGENIG
LLGISHDVTDWYNMQRQLREEMEKRRDTEVALAQRDTILQNILESSPDSIGIFNENMVYQ
ACNQPFVEALGIAEVSDLVGKRLQDVIPEHIYARLSDTDSQVLHQGKSLRYIDRIERSDG
EFIWFDVVKSPFRDPASGTNGVLIMARDVSERYLAAEQLEAANQELERLSFLDSLTHVAN
RRRFDEQLHTLWHLHVREGKPLSIILCDVDYFKDYNDAYGHLMGDETLKQIAIAFTQVAN
RHSDCVARYGGEEFGILLPNTPQSGAILVAERIHEKVRGLAIPHDHSKVADRITVSLGIV
TLIPRPEDVPEQMVELADRALYQAKANGRNQTSIYQPNH