Protein Info for CSW01_11920 in Vibrio cholerae E7946 ATCC 55056

Annotation: NupC/NupG family nucleoside CNT transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 418 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 31 to 51 (21 residues), see Phobius details amino acids 90 to 124 (35 residues), see Phobius details amino acids 173 to 193 (21 residues), see Phobius details amino acids 201 to 220 (20 residues), see Phobius details amino acids 263 to 288 (26 residues), see Phobius details amino acids 296 to 314 (19 residues), see Phobius details amino acids 358 to 382 (25 residues), see Phobius details amino acids 395 to 416 (22 residues), see Phobius details TIGR00804: nucleoside transporter, NupC family" amino acids 5 to 415 (411 residues), 505.2 bits, see alignment E=7.2e-156 PF01773: Nucleos_tra2_N" amino acids 8 to 81 (74 residues), 94.1 bits, see alignment E=9.1e-31 PF07670: Gate" amino acids 98 to 196 (99 residues), 72.1 bits, see alignment E=7e-24 PF07662: Nucleos_tra2_C" amino acids 201 to 413 (213 residues), 271.1 bits, see alignment E=1.1e-84

Best Hits

Swiss-Prot: 66% identical to Y519_HAEIN: Uncharacterized transporter HI_0519 (HI_0519) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K03317, concentrative nucleoside transporter, CNT family (inferred from 100% identity to vcj:VCD_001997)

MetaCyc: 58% identical to purine nucleobase/nucleoside transporter (Helicobacter pylori 26695)
TRANS-RXN-195; TRANS-RXN-495

Predicted SEED Role

"Na+ dependent nucleoside transporter NupC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (418 amino acids)

>CSW01_11920 NupC/NupG family nucleoside CNT transporter (Vibrio cholerae E7946 ATCC 55056)
MSLFMSLIGMAVLLGIAVLLSSNRKAINLRTVGGAFAIQFSLGAFILYVPWGQELLRGFS
DAVSNVINYGNDGTSFLFGGLVSGKMFEVFGGGGFIFAFRVLPTLIFFSALISVLYYLGV
MQWVIRILGGGLQKALGTSRAESMSAAANIFVGQTEAPLVVRPFVPKMTQSELFAVMCGG
LASIAGGVLAGYASMGVKIEYLVAASFMAAPGGLLFAKLMMPETEKPQDNEDITLDGGDD
KPANVIDAAAGGASAGLQLALNVGAMLIAFIGLIALINGMLGGIGGWFGMPELKLEMLLG
WLFAPLAFLIGVPWNEATVAGEFIGLKTVANEFVAYSQFAPYLTEAAPVVLSEKTKAIIS
FALCGFANLSSIAILLGGLGSLAPKRRGDIARMGVKAVIAGTLSNLMAATIAGFFLSF