Protein Info for CSW01_11885 in Vibrio cholerae E7946 ATCC 55056

Annotation: phosphoserine phosphatase SerB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 328 transmembrane" amino acids 299 to 318 (20 residues), see Phobius details PF18429: DUF5609" amino acids 33 to 97 (65 residues), 56 bits, see alignment E=5.8e-19 TIGR00338: phosphoserine phosphatase SerB" amino acids 103 to 312 (210 residues), 283.5 bits, see alignment E=1.1e-88 PF00702: Hydrolase" amino acids 109 to 281 (173 residues), 73.9 bits, see alignment E=4.7e-24 TIGR01488: HAD phosphoserine phosphatase-like hydrolase, family IB" amino acids 109 to 279 (171 residues), 82.6 bits, see alignment E=3.5e-27 PF12710: HAD" amino acids 110 to 277 (168 residues), 51.3 bits, see alignment E=4e-17 PF08282: Hydrolase_3" amino acids 239 to 302 (64 residues), 36.3 bits, see alignment E=1e-12

Best Hits

Swiss-Prot: 100% identical to SERB_VIBCH: Phosphoserine phosphatase (VC_2345) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K01079, phosphoserine phosphatase [EC: 3.1.3.3] (inferred from 100% identity to vcm:VCM66_2268)

Predicted SEED Role

"Phosphoserine phosphatase (EC 3.1.3.3)" in subsystem Glycine and Serine Utilization or Serine Biosynthesis (EC 3.1.3.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.3

Use Curated BLAST to search for 3.1.3.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (328 amino acids)

>CSW01_11885 phosphoserine phosphatase SerB (Vibrio cholerae E7946 ATCC 55056)
MDMDALTTLPIKKHTALLNRFPETRFVTQLAKKRASWIVFGHYLTPAQFEDMDFFTNRFN
AILDMWKVGRYEVALMDGELTSEHETILKALELDYARIQDVPDLTKPGLIVLDMDSTAIQ
IECIDEIAKLAGVGEEVAEVTERAMQGELDFEQSLRLRVSKLKDAPEQILSQVRETLPLM
PELPELVATLHAFGWKVAIASGGFTYFSDYLKEQLSLDYAQSNTLEIVSGKLTGQVLGEV
VSAQTKADILLTLAQQYDVEIHNTVAVGDGANDLVMMAAAGLGVAYHAKPKVEAKAQTAV
RFAGLGGVVCILSAALVAQQKLSWKSKP