Protein Info for CSW01_11635 in Vibrio cholerae E7946 ATCC 55056

Annotation: DNA polymerase IV

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 360 PF00817: IMS" amino acids 11 to 158 (148 residues), 168.2 bits, see alignment E=1.7e-53 PF11798: IMS_HHH" amino acids 170 to 201 (32 residues), 25.7 bits, see alignment (E = 1.4e-09) PF11799: IMS_C" amino acids 244 to 352 (109 residues), 33.6 bits, see alignment E=7e-12

Best Hits

Swiss-Prot: 100% identical to DPO4_VIBCH: DNA polymerase IV (dinB) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K02346, DNA polymerase IV [EC: 2.7.7.7] (inferred from 100% identity to vco:VC0395_A1876)

MetaCyc: 62% identical to DNA polymerase IV (Escherichia coli K-12 substr. MG1655)
DNA-directed DNA polymerase. [EC: 2.7.7.7]; 2.7.7.7 [EC: 2.7.7.7]

Predicted SEED Role

"DNA polymerase IV (EC 2.7.7.7)" in subsystem DNA repair, bacterial (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (360 amino acids)

>CSW01_11635 DNA polymerase IV (Vibrio cholerae E7946 ATCC 55056)
MQDRIRKIIHVDMDCFFAAVEMRDNPAYREIALAVGGHEKQRGVISTCNYQARKFGVRSA
MPTAQALKLCPQLHVVPGRMSVYKSVSQQIQTIFQRYTSLIEPLSLDEAYLDVSESTAYQ
GSATLIAQAIRRDIWQELNLTASAGVAPIKFLAKVASDLNKPDGLYVVTPDKVQEMVDSL
PLEKIPGVGKVALEKLHQAGLYVGADVRRADYRKLLHQFGRLGASLWKKSHGIDEREVVT
ERERKSVGVEYTFSQNISTFQECWQVIEQKLYPELDARLSRAHPQRGIIKQGIKVKFADF
QQTTIEHVHPALELDYFHELLEQVLTRQQGREIRLLGLSVMLKPELQMKQLSMFPSDGWQ