Protein Info for CSW01_11435 in Vibrio cholerae E7946 ATCC 55056

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1159 TIGR00594: DNA polymerase III, alpha subunit" amino acids 6 to 1030 (1025 residues), 1395.4 bits, see alignment E=0 PF02811: PHP" amino acids 8 to 172 (165 residues), 158.3 bits, see alignment E=6.9e-50 PF07733: DNA_pol3_alpha" amino acids 292 to 558 (267 residues), 344.4 bits, see alignment E=1.5e-106 PF17657: DNA_pol3_finger" amino acids 561 to 735 (175 residues), 215.6 bits, see alignment E=8.3e-68 PF14579: HHH_6" amino acids 808 to 897 (90 residues), 99.2 bits, see alignment 3.9e-32 PF01336: tRNA_anti-codon" amino acids 999 to 1071 (73 residues), 42.7 bits, see alignment 1.3e-14 PF20914: DNA_pol_IIIA_C" amino acids 1099 to 1150 (52 residues), 92.4 bits, see alignment (E = 3.7e-30)

Best Hits

Swiss-Prot: 100% identical to DPO3A_VIBCH: DNA polymerase III subunit alpha (dnaE) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 82% identity to vsa:VSAL_I2412)

MetaCyc: 76% identical to DNA polymerase III subunit alpha (Escherichia coli K-12 substr. MG1655)
DNA-directed DNA polymerase. [EC: 2.7.7.7]

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1159 amino acids)

>CSW01_11435 DNA polymerase III subunit alpha (Vibrio cholerae E7946 ATCC 55056)
MSDPKFIHLRIHSDFSMVDGLSKVPPLVKKVAAMGMPAMALTDFTNLCGLVKFYSTAHNC
GVKPIIGADFTLQSEEFGDELTKLTLLAKNNVGYKNLTLLISKAYLRGHVQHQPVIDKAW
LVEHAEGLIVLSGGKSGEVGRALLKGNQQQVERCIEFYQTHFADHFYLELIRTGRADEES
YLHFALDVAEQYDLPVVATNEVVFITEESFEAHEIRVAIHDGYTLEDPRRPKNYSPKQYL
RSEAEMCELFADIPEALANSVEIAKRCNVTVRLGEYFLPNFPTGGMAIEDFLVMKSREGL
EERLEFLFPDPEVRAKRRPEYDERLQVELDVINQMGFPGYFLIVMEFIQWSKDNDIPVGP
GRGSGAGSLVAYALKITDLDPLEYDLLFERFLNPERVSMPDFDVDFCMDKRDQVIDHVAE
MYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPFGFVDRISKLVPPDPGMTLEKAFIAEPA
LQELYDADEEVKELIDKCRILEGCTRNAGKHAGGVVISPTAITDFAPIYCDAEGNFPVTQ
FDKNDVETAGLVKFDFLGLRTLTIIDWALGLVNPRLKKAGKPPVRIEAIPLDDARSFRNL
QDAKTTAVFQLESRGMKELIKRLQPDCFEDIIALVALFRPGPLQSGMVDNFIDRKHGREA
ISYPDEKWQHESLKEILEPTYGIILYQEQVMQIAQVLSGYTLGGADMLRRAMGKKKPEEM
AKQRAVFQEGAEKNGVDGELAMKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKTHYPA
EFMAAVMTADMDNTEKVVGLVDECKNMGLTVLPPDINSGLYRFNVDDNGAIVYGIGAIKG
VGEGPIEAILEARNKGGYFKDLFDFCARIDLKKVNKRVIEKLILAGALDRLGPHRAAMMA
SVDDAVRAASQHHQAEAFGQADMFGVLTDAPEEVEQKYTQVPEWPEKVRLEGERETLGLY
LTGHPVDEYLKELTKYTSCRLNEAAPTRRDQSLTVAGLVIAARVMTTKRGTRIGLMTLDD
RSGRMEVMLYSEALDRYAEWLEKDKILVVSGQVSFDDFNGGLKMSAREVMDLGSAREKFA
RGLSISILQSQIDQQFFERFSHILEPHRAGTVPVNVYYQRPDARARLTLGTEWRVTPSDT
LLDELKQLLGHDQVELEFN