Protein Info for CSW01_11395 in Vibrio cholerae E7946 ATCC 55056

Annotation: hydroxyacylglutathione hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 252 TIGR03413: hydroxyacylglutathione hydrolase" amino acids 4 to 252 (249 residues), 345 bits, see alignment E=1.1e-107 PF00753: Lactamase_B" amino acids 13 to 166 (154 residues), 78.5 bits, see alignment E=7e-26 PF16123: HAGH_C" amino acids 167 to 252 (86 residues), 96.8 bits, see alignment E=8.3e-32

Best Hits

Swiss-Prot: 100% identical to GLO2_VIBCM: Hydroxyacylglutathione hydrolase (gloB) from Vibrio cholerae serotype O1 (strain M66-2)

KEGG orthology group: K01069, hydroxyacylglutathione hydrolase [EC: 3.1.2.6] (inferred from 100% identity to vco:VC0395_A1828)

MetaCyc: 47% identical to hydroxyacylglutathione hydrolase GloB (Escherichia coli K-12 substr. MG1655)
Hydroxyacylglutathione hydrolase. [EC: 3.1.2.6]

Predicted SEED Role

"Hydroxyacylglutathione hydrolase (EC 3.1.2.6)" in subsystem Glutathione: Non-redox reactions or Methylglyoxal Metabolism (EC 3.1.2.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (252 amino acids)

>CSW01_11395 hydroxyacylglutathione hydrolase (Vibrio cholerae E7946 ATCC 55056)
MLQIKSIPAFDDNYIWLIQNRDRDCAVVDPGSAEPVLAYLKQHDLNLKAVLITHHHHDHI
GGVAELVHQFPEIHVVGPAQEPIPTLTHPVEDGDQIELFDERFMVLGLPGHTLGHIGYVG
DGKLFCGDVLFSAGCGRVFEGTMEQMFSSLNKLLSLPEETQVYSAHEYTAANVAFALAVE
PENEQLHIYRDEVSRLRAQNQPTLPTTLGREKWVNPFLRTQEPSVIRSVASQVSTLDPLT
IFTALREWKNEF