Protein Info for CSW01_11310 in Vibrio cholerae E7946 ATCC 55056

Annotation: beta-N-acetylhexosaminidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 883 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF03173: CHB_HEX" amino acids 35 to 193 (159 residues), 226.7 bits, see alignment E=2.4e-71 PF02838: Glyco_hydro_20b" amino acids 210 to 329 (120 residues), 63.8 bits, see alignment E=5.6e-21 PF00728: Glyco_hydro_20" amino acids 332 to 764 (433 residues), 333.6 bits, see alignment E=3.4e-103 PF03174: CHB_HEX_C" amino acids 804 to 879 (76 residues), 97.9 bits, see alignment E=5.2e-32

Best Hits

Swiss-Prot: 77% identical to CHB_VIBHA: N,N'-diacetylchitobiase (chb) from Vibrio harveyi

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 100% identity to vcj:VCD_002121)

Predicted SEED Role

"Beta-hexosaminidase (EC 3.2.1.52)" in subsystem Chitin and N-acetylglucosamine utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 3.2.1.52)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (883 amino acids)

>CSW01_11310 beta-N-acetylhexosaminidase (Vibrio cholerae E7946 ATCC 55056)
MLKKSLISIAVFTSLSGCALNTTSPQEVVDTLANNLDVQYQVVNNHGADTGLACQTLEAE
WASCNQVNMTLVNRGEAVNSKDWAIYFHSIRLILDVGNDQFKITRVTGDLHKLEPTDKFD
GFAAGETVTLPLIGEYWTLFETDFMPRAFVTAPDAEPKVIAALNTEDVASFVSGLEGENL
KRTPSDNNVFAQALSRFEKNSDVALQDVTHALIPTPLQVKSHSGSVSIAKGIALPSKAFD
GEQMQALNERAQLLGVNLKGVMPAQVIINPKSFKGDLAKSGAYRLAITDKAVKVTAFDQA
GAFYAMQSLLGLVDMADATQLPKVEIVDAPRFDYRGVMVDVARNFHSKQAILATLDQMAA
YKMNKLHLHLTDDEGWRIEIPGLPELTDIGAQRCFDPSETECVLPQLGSGPNADNFGSGY
FTKQDYLEILQYAKARHIEVIPEIDMPAHARAAVVSMEARYQRLMQEGNEAAANEFRLLD
PQDTSNVTTVQFYDRMSFINPCLDSSKRFVDKVISEIAAMHQAAGMPLTTWHFGGDEAKN
IKLGAGFQDVNTQEPVSWKGNLDLSKQDKPFARSPQCQNLIATGAVSDFGHLPSYFAEQV
SKLVAEKGIPNFQAWQDGLKYSEGEKAFATENTRVNFWDVLYWGGSASAYEWAEKGYDVI
ISNPDYVYMDMPYEADPKERGYYWATRATDTRKMFGFAPENLPQNAETSLDRDGNGFSGK
GEVKGKPFYGLSAQLWSETVRTDEQYEYMVFPRVLAAAERAWHRAEWENAYKVGVEYSQE
TQLVNHKALNADWNRFANVLGQRELAKLEKAGIDYRLPVPGAKIENGHLAMNVQFPGVTL
QYSLDGQTWLDYDAKQAPKVSGEVWIRSVSASGERTSRVTSLK