Protein Info for CSW01_11300 in Vibrio cholerae E7946 ATCC 55056

Annotation: copper-exporting P-type ATPase A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 915 transmembrane" amino acids 263 to 285 (23 residues), see Phobius details amino acids 291 to 313 (23 residues), see Phobius details amino acids 329 to 348 (20 residues), see Phobius details amino acids 359 to 377 (19 residues), see Phobius details amino acids 512 to 533 (22 residues), see Phobius details amino acids 539 to 563 (25 residues), see Phobius details amino acids 854 to 873 (20 residues), see Phobius details amino acids 879 to 899 (21 residues), see Phobius details PF00403: HMA" amino acids 177 to 233 (57 residues), 48.9 bits, see alignment 1.4e-16 TIGR01511: copper-translocating P-type ATPase" amino acids 308 to 904 (597 residues), 614.8 bits, see alignment E=3.3e-188 TIGR01525: heavy metal translocating P-type ATPase" amino acids 327 to 903 (577 residues), 615.6 bits, see alignment E=2e-188 TIGR01494: HAD ATPase, P-type, family IC" amino acids 366 to 872 (507 residues), 313.9 bits, see alignment E=3.1e-97 PF00122: E1-E2_ATPase" amino acids 395 to 575 (181 residues), 169.1 bits, see alignment E=1.5e-53 PF00702: Hydrolase" amino acids 592 to 808 (217 residues), 125 bits, see alignment E=9.9e-40 PF08282: Hydrolase_3" amino acids 782 to 840 (59 residues), 26.9 bits, see alignment 7.7e-10

Best Hits

Swiss-Prot: 100% identical to COPA_VIBCH: Copper-exporting P-type ATPase (copA) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 100% identity to vcm:VCM66_2138)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (915 amino acids)

>CSW01_11300 copper-exporting P-type ATPase A (Vibrio cholerae E7946 ATCC 55056)
MDIPQGGVIMNHFALALRGLNCMGCARKLERQLNQDLTVEIETLTPTSIELHTHATLNEV
LTSIESLGYQGGTEQTYQLQGLNCGRCVNKLTTHLSAQAEIAKLHVSKERLSLVTTLTAE
QVKALVAEVGYQAIEAEQESTFAPAASIDEKETDTPDAENSSNTEATEASSQTLSLLIKG
MTCASCVASVEKALLSVEGVQSAQVNLTEQSALVRGIFANPQPLLNAIQSSGYQAEILDD
PAQQQAKQQAQLEALQKEHKQSALLGIALGTPLMLWGVFGGNMMIRNSSDQMVWGGIGTI
CFALLLTAGRHFFMNAWQALTHGRATMDTLVALGTGAAWFYSMLVVAWPQTFPDAARHVY
FEATAMIIGLISLGHYIETKAKSNTNRSLQALLNLQPQQATLVTEQGDQSIAVADIQLGM
SLRIKPGEQVPVDGVVSTGHSYLDESMLTGEPIPVLKEAGAKVAAGTLNQDGSLVITATG
IGAQTMLARIIQMVRQAQSSKPAMARLADQISSVFVPVVVVIAILSAALWYLYGPDPKAS
YMLVVATTVLIIACPCALGLATPLSITVGIGKAAEMGILIRDANVLQTASQVDTVVFDKT
GTLTLGKPSIQSLHVLQGDENQLLALAYALEQQSEHPLAKAICDYAKQRNISPVEISQFT
NQRGRGLLADYQNQTVLVGSLAFMQEQGIDLSMAESTLEKFAAQAWTPVAVAYRGMLQGV
LAIADPIKPTSAQAVRKLNELGIHTVMLTGDHTSVANAIAKELGISQVIAQVLPDQKAQH
IQALQQQGRKVAMIGDGINDAPALALADIGIAMGSGSDVAIESAQMTLLNSSPTSVVSAI
ELSKATLRNMKQNLFGAFIYNTLGIPIAAGVLYPAFGFLLSPVVAGAAMALSSITVVSNA
NRLRWSKISFDQHSQ