Protein Info for CSW01_10470 in Vibrio cholerae E7946 ATCC 55056

Annotation: phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01132: phosphoglucomutase, alpha-D-glucose phosphate-specific
  • amino acids 1 to 544 (544 residues), 1081.4 bits, E=0
• PF02878: PGM_PMM_I
  • amino acids 40 to 180 (141 residues), 126.3 bits, E=1.4e-40
• PF02879: PGM_PMM_II
  • amino acids 210 to 317 (108 residues), 53.3 bits, E=7.1e-18
• PF02880: PGM_PMM_III
  • amino acids 320 to 438 (119 residues), 101.6 bits, E=6.2e-33
• PF00408: PGM_PMM_IV
  • amino acids 490 to 535 (46 residues), 23.8 bits, 7.6e-09

Best Hits

Swiss-Prot: 70% identical to PGM_ECOLI: Phosphoglucomutase (pgm) from Escherichia coli (strain K12)

KEGG orthology group: K01835, phosphoglucomutase [EC: 5.4.2.2] (inferred from 100% identity to vcj:VCD_002272)

MetaCyc: 71% identical to phosphoglucomutase (Yersinia enterocolitica (type O:8))
Phosphoglucomutase. [EC: 5.4.2.2]

Predicted SEED Role

"Phosphoglucomutase (EC 5.4.2.2)" (EC 5.4.2.2)

MetaCyc Pathways

• D-galactose degradation I (Leloir pathway) (5/5 steps found)
• superpathway of anaerobic sucrose degradation (15/19 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (4/4 steps found)
• colanic acid building blocks biosynthesis (9/11 steps found)
• UDP-α-D-glucose biosynthesis (2/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• sucrose degradation II (sucrose synthase) (4/5 steps found)
• starch degradation V (3/4 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• glucosylglycerol biosynthesis (3/5 steps found)
• glycogen degradation I (5/8 steps found)
• sucrose biosynthesis II (5/8 steps found)
• starch degradation III (2/4 steps found)
• GDP-α-D-glucose biosynthesis (1/3 steps found)
• trehalose degradation V (1/3 steps found)
• starch biosynthesis (6/10 steps found)
• glycogen degradation II (3/6 steps found)
• chitin biosynthesis (5/9 steps found)
• glucose and glucose-1-phosphate degradation (2/5 steps found)
• O-antigen building blocks biosynthesis (E. coli) (6/11 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (1/5 steps found)
• dTDP-β-L-rhamnose biosynthesis (1/5 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (2/8 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (2/19 steps found)
• streptomycin biosynthesis (1/18 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (9/33 steps found)

KEGG Metabolic Maps

• Galactose metabolism
• Glycolysis / Gluconeogenesis
• Nucleotide sugars metabolism
• Pentose phosphate pathway
• Starch and sucrose metabolism
• Streptomycin biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.2.2

Protein Sequence (548 amino acids)

>CSW01_10470 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (Vibrio cholerae E7946 ATCC 55056)
MAMHPRAGQKARQEDLHNIPALVANYYLLQPEAGNTAHKVEFGTSGHRGTADKTTFNEHH
ILAIAQAVADVRHEHGVTGPIFIGKDTHALSEPAFSSVLEVLIANGIEVIVQENNGYTPT
PGISHAILTYNLKHADKADGIVITPSHNPPQDGGIKYNPPHGGPAEGELTQAIEDRANAY
ISQQLAGVKRMPIALAKQSELLKQVDLVKPYVDDLVNVVDMAAIQKAKLKIGVDPLGGSG
IDYWRQIGNAYQLDLTLVSEAIDPSFQFMSLDKDGVIRMDCSSPYAMAGLLALKDEYDLA
FGNDPDYDRHGIVTPKGLMNPNHFLAVCIDYLYRHRQGWAGHVAVGKTLVSSAMIDKVVA
DLGRELCEVPVGFKWFVDGLYSGRFGFGGEESAGASFLRQDGTPWSTDKDGIILCLLAAE
ITAVTGKNPQQYYDELAAKHGDFYYSRIQAVANGPQKNVLKKLSPEMVSAQTLAGDAITA
RLTHAPGNGAAIGGLKVTTDYGWFAARPSGTEDIYKIYCESFKGAEHLKQIESEAQQIVN
QVFKDAGL