Protein Info for CSW01_10320 in Vibrio cholerae E7946 ATCC 55056

Annotation: chemotaxis protein CheA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 785 transmembrane" amino acids 644 to 660 (17 residues), see Phobius details PF01627: Hpt" amino acids 8 to 100 (93 residues), 58.8 bits, see alignment E=1e-19 PF02895: H-kinase_dim" amino acids 395 to 455 (61 residues), 54.5 bits, see alignment 2.6e-18 PF02518: HATPase_c" amino acids 503 to 642 (140 residues), 64.3 bits, see alignment E=2.7e-21 PF01584: CheW" amino acids 649 to 778 (130 residues), 84 bits, see alignment E=1.5e-27

Best Hits

KEGG orthology group: K03407, two-component system, chemotaxis family, sensor kinase CheA [EC: 2.7.13.3] (inferred from 100% identity to vch:VC2063)

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (785 amino acids)

>CSW01_10320 chemotaxis protein CheA (Vibrio cholerae E7946 ATCC 55056)
MSYELDEDILQDFLVEAGEILELLSEQLVELENNPEDRDLLNAIFRGFHTVKGGAGFLAL
SELVETCHGAENVFDILRNGQRHVSPSLMDTMLKALDTVNEQFRAVQEREPLQPADPELL
DELHRLSKPASEDEDEAAEAHFDEPEEELVEEIIEEVVEDVVEEAVPNVETEVTASASSG
VIDKGSIDDINEDEFEKLLDELHGKGKAPGAQSPQAPASAPAKAASVTNSDLNGDITDDE
FEKLLDQLHGKGKGPSIETAAPAAPVTPSTPKATETPKPAAAKSAPGGDDLMTDEEFEKL
LDELHGSGKGPSVEELEMATRPVASSPVSSDAKASAEASAPSTKPAAKPVAKPAAAKPAV
AKEEPAKAPAPAAVKDSDESREVAAAGGAKKAQTESTVRVDTSTLDTIMNMVGELVLVRN
RLLSLGLNSNDEEMSKAVANLDVVTADLQGAVMKTRMQPIKKVFGRFPRVVRDLARSLNK
EIDLELRGEETDLDKNLVEALADPLIHLVRNSVDHGIEMPDERAKNGKSRTGKVILSASQ
EGDHIQLAIVDDGAGMDPDKLRGIAVKRGIMDEDAANRLTNKECFNLIFMPGFSSKEKIT
DISGRGVGMDVVKTAINTLNGSIDIDSTMGKGTKITIKVPLTLAILPTLMVGVAGHPFAL
PLASVNEIFHLDLRRTNVVDGQLTIIVREKSIPLFYLQNWLAPKKGKVQLRQGHGHVVIV
QIGSQRVGLVVDTLIGQEEVVIKPLDKLLQGTPGMSGATITSDGHIALILDVPDLLKQYA
AASRV