Protein Info for CSW01_10285 in Vibrio cholerae E7946 ATCC 55056

Annotation: heme exporter protein CcmB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 222 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 47 to 68 (22 residues), see Phobius details amino acids 93 to 121 (29 residues), see Phobius details amino acids 127 to 154 (28 residues), see Phobius details amino acids 161 to 185 (25 residues), see Phobius details amino acids 194 to 217 (24 residues), see Phobius details PF03379: CcmB" amino acids 6 to 219 (214 residues), 301.8 bits, see alignment E=1.2e-94 TIGR01190: heme exporter protein CcmB" amino acids 9 to 218 (210 residues), 302.3 bits, see alignment E=9.1e-95

Best Hits

Swiss-Prot: 71% identical to CCMB_HAEIN: Heme exporter protein B (ccmB) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K02194, heme exporter protein B (inferred from 100% identity to vch:VC2056)

MetaCyc: 68% identical to cytochrome c maturation protein B (Escherichia coli K-12 substr. MG1655)
RXN-21408

Predicted SEED Role

"ABC transporter involved in cytochrome c biogenesis, CcmB subunit" in subsystem Biogenesis of c-type cytochromes

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (222 amino acids)

>CSW01_10285 heme exporter protein CcmB (Vibrio cholerae E7946 ATCC 55056)
MMPAFIQFIHRELLIAFRRQADVFNPLWFFIIVITLFPLSVGPEPALLARIAPGIVWVAA
LLAALLSLERLFRDDFQDGALEQAMLTPLPLSVVVLAKVTAHWLLTGLPLILISPLLAIL
LSFDSSAWLAVVLTLLLGTPTLSFIGAIGVALTVGLQKGGVLLSLLVLPLFIPVLIFATS
AIDAAALGMPYNGQLAILAAMLMGSMTLTPFAISAALRVSVH