Protein Info for CSW01_10080 in Vibrio cholerae E7946 ATCC 55056

Annotation: 4-amino-4-deoxychorismate lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to PABC_VIBCH: Aminodeoxychorismate lyase (pabC) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K02619, 4-amino-4-deoxychorismate lyase [EC: 4.1.3.38] (inferred from 100% identity to vcj:VCD_002349)

Predicted SEED Role

"Aminodeoxychorismate lyase (EC 4.1.3.38)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Folate Biosynthesis (EC 4.1.3.38)

MetaCyc Pathways

superpathway of chorismate metabolism (51/59 steps found)
superpathway of tetrahydrofolate biosynthesis and salvage (10/12 steps found)
superpathway of tetrahydrofolate biosynthesis (8/10 steps found)
4-aminobenzoate biosynthesis I (2/2 steps found)
4-aminobenzoate biosynthesis II (1/2 steps found)
superpathway of candicidin biosynthesis (4/11 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.3.38

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (267 amino acids)

>CSW01_10080 4-amino-4-deoxychorismate lyase (Vibrio cholerae E7946 ATCC 55056)
MYWVNGQRRNEVPIHDRSFQYGDGCFTTILTKEGQVQQWSSHKARLQACLDILHIPEPNW
DRVWQGLQSMILPQEKAGLKIHISRGLGGRGYSPTQVSESIVTISAFAFPAHYQAWRDKG
LAVGICQQRMGLNPLLAGHKHNNRLEQILLKREMDNAGWDDGVCLDINGKVIETTAANIF
WCRDGTMFTPCLRHAGVAGVARRQILELAQQQEIPIVIDEFTLEDLLSAEEVFITNALLE
VAPVTQIGQQRLTIGSMTRRFQESSNS