Protein Info for CSW01_09840 in Vibrio cholerae E7946 ATCC 55056

Annotation: o-succinylbenzoate--CoA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 14 to 334 (321 residues), 163.1 bits, E=4.6e-52
• TIGR01923: O-succinylbenzoate-CoA ligase
  • amino acids 32 to 462 (431 residues), 557.5 bits, E=1.1e-171

Best Hits

KEGG orthology group: K01911, O-succinylbenzoic acid--CoA ligase [EC: 6.2.1.26] (inferred from 100% identity to vcj:VCD_002396)

Predicted SEED Role

"O-succinylbenzoic acid--CoA ligase (EC 6.2.1.26)" in subsystem Menaquinone and Phylloquinone Biosynthesis (EC 6.2.1.26)

MetaCyc Pathways

• superpathway of chorismate metabolism (51/59 steps found)
• superpathway of menaquinol-8 biosynthesis I (10/10 steps found)
• superpathway of demethylmenaquinol-8 biosynthesis I (9/9 steps found)
• 2-carboxy-1,4-naphthoquinol biosynthesis (7/7 steps found)
• superpathway of menaquinol-10 biosynthesis (9/10 steps found)
• superpathway of menaquinol-11 biosynthesis (9/10 steps found)
• superpathway of menaquinol-12 biosynthesis (9/10 steps found)
• superpathway of menaquinol-13 biosynthesis (9/10 steps found)
• superpathway of menaquinol-6 biosynthesis (9/10 steps found)
• superpathway of menaquinol-7 biosynthesis (9/10 steps found)
• superpathway of menaquinol-9 biosynthesis (9/10 steps found)
• superpathway of demethylmenaquinol-6 biosynthesis I (8/9 steps found)
• superpathway of demethylmenaquinol-9 biosynthesis (8/9 steps found)
• superpathway of phylloquinol biosynthesis (7/15 steps found)

KEGG Metabolic Maps

• Ubiquinone and menaquinone biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.26

Protein Sequence (476 amino acids)

>CSW01_09840 o-succinylbenzoate--CoA ligase (Vibrio cholerae E7946 ATCC 55056)
MALGIFPVSLWQPWLERDPKQVALSHAGQTLTWQVLDSQVAHYAKALREQGVRSGEVVTL
VGKNHLHTVLWFLACTQVGALCAFLAPQPLARLQEKLATLYAEQSPKHLWLAPSCALSEE
DITALNAHRLSLPDERDESVGGEKVSSQFSGEQLATLIFTSGSTGTPKAVAHTHQQHLVS
ARGLLNKFAFTESDSWLLSLPLYHISGVAILYRWLAVGATLKIGTGDLQNDIAGVTHASL
VPTQLKRLLDSSSPLTLKRVLLGGSHIPVELAQMAATRGIDTWLGYGMTEAASTVTAKRV
DGLAGNGELLEHRELRLVDGRIFIAGKTLAQGYYRQGQLVPLTNEQGWFDSKDLGRWQGN
NLLIDGRADNLFISGGENVHCEEIEAVLNQHPHVQVAIVIPVQDSEFGARPVAVIRSEAE
WCQAIGDTWCQGKLEKFKWPIMYCLLPDALLDGGIKVSRAAVKAWLAANQTQFTPL