Protein Info for CSW01_09635 in Vibrio cholerae E7946 ATCC 55056

Annotation: sigma-54-dependent Fis family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 446 PF00072: Response_reg" amino acids 4 to 114 (111 residues), 81.6 bits, see alignment E=1.4e-26 PF00158: Sigma54_activat" amino acids 144 to 310 (167 residues), 238.1 bits, see alignment E=1.4e-74 PF14532: Sigma54_activ_2" amino acids 145 to 315 (171 residues), 87.7 bits, see alignment E=2.6e-28 PF07728: AAA_5" amino acids 167 to 284 (118 residues), 35.4 bits, see alignment E=3.1e-12 PF00004: AAA" amino acids 168 to 285 (118 residues), 23.4 bits, see alignment E=2.2e-08 PF02954: HTH_8" amino acids 397 to 437 (41 residues), 35.2 bits, see alignment 2.4e-12

Best Hits

Swiss-Prot: 56% identical to DCTD_RHIME: C4-dicarboxylate transport transcriptional regulatory protein DctD (dctD) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K10126, two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD (inferred from 100% identity to vco:VC0395_A1516)

Predicted SEED Role

"Two component, Sigma-54 Specific, central transcriptional regulator of acidic amino acid uptake"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (446 amino acids)

>CSW01_09635 sigma-54-dependent Fis family transcriptional regulator (Vibrio cholerae E7946 ATCC 55056)
MCDVFLIDDESDIRIALAQSFELADLNAQFFASVEEALLAIKAQGLPLVIVSDICLPGLS
GQNLLSSVLHQDSELPVILITGHGDISMAVKAMHDGAYDFIEKPFAPERLIDTVHRAIEK
RRLTLENRQLKRSLKVSQTLGPRIIGETAAIQTLRDTIAQVADTQADILLFGETGTGKEL
VARSLHEQSSRREQNFVAINCGAVPENLIESELYGHEKGAFTGADSRRVGKFEHAQGGTL
FLDEIESMPMQAQIRLLRVLQERVIERIGSNELIPLDIRVIAATKIDLKQAAAEGKFRQD
LYYRLNIVTLTIPPLRERREDIPALFHHFLLVAAARYGKAATALTASDVQSLLSHDWPGN
VRELRNAAERYVLLGKLAQFAESHEPKSKLLGLNEQVAEFEKSLLEQTLIECGGSIKATM
ERLHLPRKTLYDKMQKYQLDKESYKP