Protein Info for CSW01_09595 in Vibrio cholerae E7946 ATCC 55056

Annotation: peptidylprolyl isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 619 transmembrane" amino acids 12 to 35 (24 residues), see Phobius details PF13624: SurA_N_3" amino acids 1 to 166 (166 residues), 167.6 bits, see alignment E=5.4e-53 PF13623: SurA_N_2" amino acids 2 to 142 (141 residues), 121 bits, see alignment E=9.6e-39 PF13145: Rotamase_2" amino acids 249 to 374 (126 residues), 78.6 bits, see alignment E=1.8e-25 PF13616: Rotamase_3" amino acids 262 to 361 (100 residues), 89.2 bits, see alignment E=7.3e-29 PF00639: Rotamase" amino acids 283 to 361 (79 residues), 83.7 bits, see alignment E=3.8e-27

Best Hits

Swiss-Prot: 39% identical to PPID_ECOLI: Peptidyl-prolyl cis-trans isomerase D (ppiD) from Escherichia coli (strain K12)

KEGG orthology group: K03770, peptidyl-prolyl cis-trans isomerase D [EC: 5.2.1.8] (inferred from 100% identity to vcj:VCD_002444)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase PpiD (EC 5.2.1.8)" (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (619 amino acids)

>CSW01_09595 peptidylprolyl isomerase (Vibrio cholerae E7946 ATCC 55056)
MMDRLREGVNSIAVKIILGLIILSFIFAGVGNYLISGGNNAAAKVGNAEISRGDFEQAYQ
NERNRMQAQLGDYFSNLLADPTYVASFRKSVLDRMVNDLLLEQHAASLGLRVSDEQVRQL
ILEIPQFQSQGVFDSTAYQATLRRAGFTPEMYAEYLRKDLVRNQLMSALQGSEFSLAGEV
NLQDQLISQTRDIRTITLSLEDFAKKVTLSDEEIDQYYKTNTERFTRPEQVKVSYVELSA
DGLKAQVSVDDAAAQQYYQEHLDKYSTAEQRNVSHILIEGNDEQKAQAILDELNAGADFA
TLAKEKSQDLGSAAEGGSLGWIEPDTMDPAFEAAAFALTEKGQVSGLVKSDFGYHIIRLD
DIKAPVVKPYSEVEQAIKQELIDQQALDSFYAKQSELEKMAFEHSDSLDEAAKAISATVV
HTDFISAEQAPEVLTTPAVLQALKSPEVKEDGLNSEVIEVAPEHVVVVRVEEFRPETVLP
LDEVKSQVVEQLSRMKGEQQALELGNQLVTALKAGETDLLAQKGVSFGELQMIDRSSPLA
NTVYAMVKPQEGEKVYAQAKDFDGNIVVIELSKVESKLTPAYHEQIATQLERIGSQQDLA
GVISVLRQNTDIEYHIATE