Protein Info for CSW01_09515 in Vibrio cholerae E7946 ATCC 55056

Annotation: Na+/H+ antiporter NhaB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 530 transmembrane" amino acids 20 to 39 (20 residues), see Phobius details amino acids 44 to 63 (20 residues), see Phobius details amino acids 90 to 110 (21 residues), see Phobius details amino acids 117 to 117 (1 residues), see Phobius details amino acids 121 to 146 (26 residues), see Phobius details amino acids 148 to 166 (19 residues), see Phobius details amino acids 201 to 222 (22 residues), see Phobius details amino acids 242 to 263 (22 residues), see Phobius details amino acids 302 to 341 (40 residues), see Phobius details amino acids 353 to 372 (20 residues), see Phobius details amino acids 393 to 417 (25 residues), see Phobius details amino acids 456 to 475 (20 residues), see Phobius details amino acids 482 to 501 (20 residues), see Phobius details TIGR00774: Na+/H+ antiporter NhaB" amino acids 1 to 516 (516 residues), 992.7 bits, see alignment E=2.3e-303 PF06450: NhaB" amino acids 1 to 515 (515 residues), 977.4 bits, see alignment E=1.9e-298 PF03600: CitMHS" amino acids 72 to 336 (265 residues), 59.3 bits, see alignment E=3.6e-20

Best Hits

Swiss-Prot: 100% identical to NHAB_VIBCH: Na(+)/H(+) antiporter NhaB (nhaB) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K03314, Na+:H+ antiporter, NhaB family (inferred from 100% identity to vco:VC0395_A1491)

Predicted SEED Role

"Na+/H+ antiporter NhaB" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (530 amino acids)

>CSW01_09515 Na+/H+ antiporter NhaB (Vibrio cholerae E7946 ATCC 55056)
MPMSLGNAFIKNFLGKAPDWYKVAIIAFLIINPIVFFFINPFLAGWLLVVEFIFTLAMAL
KCYPLQPGGLLAIEAIAIGMTSPGQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTK
ILLGIRSKVLLSIAFSVTAAFLSAFLDALTVIAVIISVAVGFYSIYHKVASGQSVHSSHD
HTHDEGISELTRDDLENYRAFLRSLLMHAGVGTALGGVTTMVGEPQNLIIADQAGWQFGE
FLLRMAPVTVPVFIAGMLTCMLVEKFRIFGYGARLPANVRQILLDFDSEERKNRTNQDVA
KLWVQGAIAVWLIVGLALHLAAVGLIGLSVIILATAFTGVIEEHSLGKAFEEALPFTALL
AVFFSIVAVIIDQELFKPVIDAVLNVEDHGTQLALFYVANGLLSMVSDNVFVGTVYITEV
KTALMEGMISRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVI
MAFPYTLALSLVGFIGIMFLLEPMTEVFYSLGWISHHVAPAADALLQSGH