Protein Info for CSW01_09445 in Vibrio cholerae E7946 ATCC 55056
Annotation: transcription-repair coupling factor
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K03723, transcription-repair coupling factor (superfamily II helicase) [EC: 3.6.4.-] (inferred from 73% identity to vsa:VSAL_II0696)Predicted SEED Role
"Transcription-repair coupling factor" in subsystem DNA-replication or Transcription factors bacterial
Isozymes
Compare fitness of predicted isozymes for: 3.6.4.-
Use Curated BLAST to search for 3.6.4.-
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (1155 amino acids)
>CSW01_09445 transcription-repair coupling factor (Vibrio cholerae E7946 ATCC 55056) MTTHSLLSLFSAQGAGDKKAIGNLHGASLALAIAELANAHTSHTLLAVPDPQTALKLLHE VEQFSHSEVALFPDWETLPYDNFSPHQDIISDRISRLYQLPSLTRGITIVPVSTLLQRQS PRDFLLQHTLIVKRGDHFSLDKLRLQLENSSYRHVDQVFGPGEYASRGSILDLFPMGSSD PFRIDFFDDEIDTIRTFDPDNQRSIAEMDEIRLLPAHEFPTTAAAIEEFRNRWRQRFEAR REPESVYSQVSKGTWPAGIEYWQPLFFEHSETLFDYLPANSQLLVVGELEKAIDQFLTDV DYRYDQRNIDPLRPLLPPNELWLRKDELFAHFKTLPQVQLTSSPIELRAGRMNAQVQPLP VLAVEHQNKEPLAALRQFSEQFTGKIIFSVESEGRREALLELLQRIKLRPQSQNDFSLAC QQTEKYSLVLGSAERGFIYGDNQVALICESDLLGDRVIQRRRKKDRKNVTNSDAVIRNLA ELKPGQPVVHIDHGIGRYLGLQTLEAGGMVSEYVMLEYQNEAKLYVPVSSLNLISRYSGG AEEAAQLHKLGGEAWVKARRKAAEKVRDVAAELLDVYAKREIKPGFKFHLDREQYATFKA TFPFEETDDQAMAINAVLSDMCQAKAMDRLVCGDVGFGKTEVAMRAAFVATDNGKQVAVL VPTTLLAQQHFENFRDRFANLPIRVEVLSRFKSAKEQKQILQDVADGKVDILVGTHKLLS SEIRFADLGLLIVDEEHRFGVRQKEKVKAMRADVDILTLTATPIPRTLNMAMSGMRDLSI IATPPARRLAIKTFVRQSEDSVIREAVLREIMRGGQVYFLHNQVETIDKVAADLEKLVPE ARITVAHGQMRERELEKVMNDFYHQRFNLLVCTTIIETGIDVPTANTIIMDRADSLGLAQ LHQLRGRVGRSHHQAYAYLLTPPPKAITKDAVKRLEAIASLEDLGAGFTLATHDLEIRGA GELLGEEQSGQIQSVGFTLYMEMLEQAVEALKSGKEPALDDLLREQTEVEMRLPALLPEE YIPDINTRLSMYKQIASVASKDELAELKVELIDRFGKLPDAALNLLAIAELKLNAMRLKV RKIEAHERGGYVEFYPNADINPVFLVKLLQSQPKLLAMDGPTKLKFTLPLVERSARIQFV ADMLKNFQQNVLPAR