Protein Info for CSW01_08900 in Vibrio cholerae E7946 ATCC 55056

Annotation: N-acetylneuraminate epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 384 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details TIGR03547: mutatrotase, YjhT family" amino acids 28 to 376 (349 residues), 491.1 bits, see alignment E=8.8e-152 PF24996: NANM" amino acids 28 to 382 (355 residues), 441 bits, see alignment E=9.5e-136 PF07646: Kelch_2" amino acids 81 to 129 (49 residues), 26.5 bits, see alignment 1.6e-09 PF13418: Kelch_4" amino acids 81 to 133 (53 residues), 29 bits, see alignment 2.8e-10 PF01344: Kelch_1" amino acids 81 to 129 (49 residues), 36.2 bits, see alignment 1.2e-12 PF13964: Kelch_6" amino acids 84 to 127 (44 residues), 25.4 bits, see alignment 3.9e-09 PF13415: Kelch_3" amino acids 90 to 140 (51 residues), 25.3 bits, see alignment 4.8e-09

Best Hits

Swiss-Prot: 100% identical to NANM_VIBC3: N-acetylneuraminate epimerase (nanM) from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_A1372)

Predicted SEED Role

"Sialic acid-induced transmembrane protein YjhT(NanM), possible mutarotase" in subsystem Sialic Acid Metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (384 amino acids)

>CSW01_08900 N-acetylneuraminate epimerase (Vibrio cholerae E7946 ATCC 55056)
MNMKTLLTYATLLSVTAFSHVVYADNQWPDLPTGFKDGVGAQVGSKVYVGLGSLGKSFYV
LDLNALSKGWQKIADFTGAERSGATASVIGNYIYLFGGSGKAEPSDPSPILFDSVYRYDT
KKDSWEKMNTTSPVGLLGASSYSPDNRQILFFGGYNKAYFDRYLRDISTTDKQVNPEVWQ
RIVDDYMGMTPTDYKWNRNVISYLPEKQEWRDLGVSTYLPNCGSATVIEGNKVTLISGEI
KPGLRTAEVKQYEFGMDQPWKSLLPLPAPQTSNIQEGVAGAFSGKTNGVVVVAGGANFHG
AKQAFENGKMFAHEGLPKAFNSEIYVEKEGIWSTVNSLPEGLAYGASFTTSEGVLIVGGE
KSGKEMSHKVYMLAWNGSTVEVID