Protein Info for CSW01_08790 in Vibrio cholerae E7946 ATCC 55056

Annotation: mechanosensitive ion channel protein MscS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 569 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 298 to 318 (21 residues), see Phobius details amino acids 343 to 363 (21 residues), see Phobius details amino acids 370 to 394 (25 residues), see Phobius details PF00924: MS_channel_2nd" amino acids 389 to 456 (68 residues), 76 bits, see alignment E=2.1e-25 PF21082: MS_channel_3rd" amino acids 462 to 544 (83 residues), 61.1 bits, see alignment E=1.1e-20

Best Hits

KEGG orthology group: K03442, small conductance mechanosensitive channel (inferred from 100% identity to vcj:VCD_002632)

Predicted SEED Role

"Small-conductance mechanosensitive channel"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (569 amino acids)

>CSW01_08790 mechanosensitive ion channel protein MscS (Vibrio cholerae E7946 ATCC 55056)
MKPRWSWVALLLLMATSAFASDTSQENTQIETTTEITTTAESPSELENEIDQIKQYISEL
SVTLKQATGDVRDALQLQLFQKNAELRKSLSKAVEEKTIAKEKLVELVNIQQRYTEEANH
YISERLNSLDDSLGKASHEEKLSYITTYRELQQYLDVTYHSSAENIGWLSSLDIDTRDVE
KTLRERINQRLRLLSASLEYLKQQISVINNQIKSSPESEKANLQLALLFTQQRLDIVTKS
LRSVVGIADQFEIETADYKRQIFQVTGSITQDLLNTQVVFSIVRHWSNSLVNWLASNAVQ
HLFQLFIFLLILLAAKGGAKVTRTVVRSAVNSKNIRISHLMQDFFVSMSGKVVWVIGILV
GLSQIGLNLAPVLTGFGIAGVIIGFALQDTLSNFAAGMMLLIYRPFDVGDFVHAGGVDGK
VSHMSLVNTTIRTFDNQIIIVPNSKIWGDVIKNVTHERIRRVDMVFGIGYSDDLLKAEAV
LTDIVKSHPAVLKTPEPNIKVHTLNTSSIDFIVRPWVKTDDYWDVYWDVTKEVKLRFDRE
GISIPFPQQDVHLHLVDQKAFIPPTQPTS